Document Detail


Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa.
MedLine Citation:
PMID:  10969724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Curcumin I, curcumin II (monodemethoxycurcumin) and curcumin III (bisdemethoxycurcumin) from Curcuma longa were assayed for their cytotoxicity, antioxidant and anti-inflammatory activities. These compounds showed activity against leukemia, colon, CNS, melanoma, renal, and breast cancer cell lines. The inhibition of liposome peroxidation by curcumins I-III at 100 microg/ml were 58, 40 and 22%, respectively. The inhibition of COX-I and COX-II enzymes by the curcumins was observed. Curcumins I-III were active against COX-I enzyme at 125 microg/ml and showed 32, 38.5 and 39.2% inhibition of the enzyme, respectively. Curcumins I-III also showed good inhibition of the COX-II enzyme at 125 mg/ml with 89.7, 82.5 and 58.9% inhibition of the enzyme, respectively.
Authors:
R S Ramsewak; D L DeWitt; M G Nair
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  7     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-12-13     Completed Date:  2001-03-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
Affiliation:
Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Antineoplastic Agents, Phytogenic / pharmacology*
Antioxidants / pharmacology*
Coumaric Acids / pharmacology
Curcumin / analogs & derivatives,  pharmacology*
Cyclooxygenase Inhibitors / pharmacology*
Humans
Tumor Cells, Cultured / drug effects
Zingiberales*
Grant Support
ID/Acronym/Agency:
1-S10-RR04750/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antineoplastic Agents, Phytogenic; 0/Antioxidants; 0/Coumaric Acids; 0/Cyclooxygenase Inhibitors; 24939-16-0/bis(4-hydroxycinnamoyl)methane; 24939-17-1/demethoxycurcumin; 458-37-7/Curcumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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