Document Detail


Cytotoxic withanolides from Physalis angulata L.
MedLine Citation:
PMID:  17372946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four new withanolides, physagulins L-O (1-4), were isolated from the MeOH extract of the aerial parts of Physalis angulata L. (Solanaceae), together with seven known withanolides, compounds 5-11. Their structures were determined by spectroscopic techniques, including 1H-, 13C-NMR (DEPT), and 2D-NMR (HMBC, HMQC, 1H,1H-COSY, NOESY) experiments, as well as by HR-MS. All eleven compounds were tested for their antiproliferative activities towards human colorectal-carcinoma (HCT-116) and human non-small-cell lung-cancer (NCI-H460) cells. Compound 5 exhibited the highest anticancer activity against the HCT-116 cell line, with an IC50 value of 1.64+/-0.06 microM. Compound 9 exhibited the highest cytotoxicity towards the NCI-H460 cell line, with an IC50 value of 0.43+/-0.02 microM.
Authors:
Qing-Ping He; Lei Ma; Jie-Ying Luo; Fu-Yuan He; Li-Guang Lou; Li-Hong Hu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  4     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-05-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  443-9     Citation Subset:  IM    
Affiliation:
Shanghai Institute of Materia Medica, Shanghai 201203, PR. China.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemistry,  isolation & purification
Cell Line, Tumor
Cytotoxins / chemistry,  isolation & purification*
Humans
Physalis*
Plant Components, Aerial*
Plant Extracts / chemistry,  isolation & purification
Withania
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Cytotoxins; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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