Document Detail


Cytotoxic triterpenoids from the fruits of Zizyphus jujuba.
MedLine Citation:
PMID:  14735446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The following eleven triterpenoic acids were isolated from the fruits of Zizyphus jujuba (Rhamnaceae): colubrinic acid, alphitolic acid, 3-O-cis-p-coumaroylalphitolic acid (3), 3-O-trans-p-coumaroylalphitolic acid (4), 3-O-cis-p-coumaroylmaslinic acid, 3-O-trans-p-coumaroylmaslinic acid, betulinic acid (7), oleanolic acid, betulonic acid (9), oleanonic acid and zizyberenalic acid. The in vitro cytotoxicities of the triterpenoic acids against K562, B16(F-10), SK-MEL-2, PC-3, LOX-IMVI, and A549 tumor cell lines were investigated by the sulforhodamin B (SRB) method. Among these compounds, the lupane-type triterpenes, such as compounds 3, 4, 7, and 9, showed high cytotoxic activities. In particular, the cytotoxic activities of 3-O-p-coumaroylalphitolic acids (compounds 3 and 4) were better than those of non-coumaroic triterpenenoids (compounds 7 and 9). These results suggest that the coumaroyl moiety at the C-3 position of the lupane-type triterpene may play an important role in enhancing cytotoxic activity.
Authors:
Sang Myung Lee; Bung Sun Min; Cheal-Gyu Lee; Kab-Sig Kim; Yung Hee Kho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  69     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2004-01-21     Completed Date:  2004-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1051-4     Citation Subset:  IM    
Affiliation:
KT&G Central Research Institute, Yuseong, Daejon, Korea.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry,  pharmacology*
Cell Line, Tumor / drug effects
Fruit
Humans
Inhibitory Concentration 50
Phytotherapy*
Plant Extracts / chemistry,  pharmacology*
Triterpenes / chemistry,  pharmacology*
Ziziphus*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 0/Triterpenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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