| Cytotoxic triterpenoids from the fruits of Zizyphus jujuba. | |
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MedLine Citation:
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PMID: 14735446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The following eleven triterpenoic acids were isolated from the fruits of Zizyphus jujuba (Rhamnaceae): colubrinic acid, alphitolic acid, 3-O-cis-p-coumaroylalphitolic acid (3), 3-O-trans-p-coumaroylalphitolic acid (4), 3-O-cis-p-coumaroylmaslinic acid, 3-O-trans-p-coumaroylmaslinic acid, betulinic acid (7), oleanolic acid, betulonic acid (9), oleanonic acid and zizyberenalic acid. The in vitro cytotoxicities of the triterpenoic acids against K562, B16(F-10), SK-MEL-2, PC-3, LOX-IMVI, and A549 tumor cell lines were investigated by the sulforhodamin B (SRB) method. Among these compounds, the lupane-type triterpenes, such as compounds 3, 4, 7, and 9, showed high cytotoxic activities. In particular, the cytotoxic activities of 3-O-p-coumaroylalphitolic acids (compounds 3 and 4) were better than those of non-coumaroic triterpenenoids (compounds 7 and 9). These results suggest that the coumaroyl moiety at the C-3 position of the lupane-type triterpene may play an important role in enhancing cytotoxic activity. |
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Authors:
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Sang Myung Lee; Bung Sun Min; Cheal-Gyu Lee; Kab-Sig Kim; Yung Hee Kho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Planta medica Volume: 69 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2004-01-21 Completed Date: 2004-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 1051-4 Citation Subset: IM |
Affiliation:
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KT&G Central Research Institute, Yuseong, Daejon, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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chemistry,
pharmacology* Cell Line, Tumor / drug effects Fruit Humans Inhibitory Concentration 50 Phytotherapy* Plant Extracts / chemistry, pharmacology* Triterpenes / chemistry, pharmacology* Ziziphus* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 0/Triterpenes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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