Document Detail


Cytotoxic terpenoids from the fruits of Vitex trifolia L.
MedLine Citation:
PMID:  19156599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new labdane-type diterpenoids vitetrifolin H (1) and vitetrifolin I (2), and one new monoterpenoid vitexoid (3), were isolated from the fruits of Vitex trifolia L., together with seven known diterpenoids. Structures of all compounds were elucidated by extensive spectroscopic methods. All these compounds exhibited inhibition of Hela cell proliferation, with IC50 values in the range of 4-28 microM. In addition, vitetrifolin I (2) induced cell cycle G0/G1 phase arrest and apoptosis of Hela cells.
Authors:
Jun Wu; Tong Zhou; Shu-wei Zhang; Xiao-hui Zhang; Li-jiang Xuan
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Publication Detail:
Type:  Journal Article     Date:  2009-01-20
Journal Detail:
Title:  Planta medica     Volume:  75     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  367-70     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry,  pharmacology*
Fruit / chemistry*
Hela Cells
Humans
Molecular Structure
Terpenes / chemistry*,  pharmacology*
Vitex / chemistry*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Terpenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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