Document Detail


Cytotoxic principles from Ventilago leiocarpa.
MedLine Citation:
PMID:  11374975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three new anthraquinones, islandicin 4-methyl ether (1), 1,2,6-trihydroxy-7,8-dimethoxy-3-methylanthraquinone (2), and 2-hydroxyemodin 1-methyl ether (3) as well as two known triterpenoids [taraxerol (4), lupeol (5)], six anthraquinones [chrysophanol (6), islandicin (8), parietin (9), emodin (10), catenarin (11), skyrin (15)], a 2,3-dihydroflavonol [(+)-aromadendrin (12)], two benzisochromanquinones [ventiloquinone K (13) and ventiloquinone I (14)], and stigmasterol (7) were isolated from Ventilago leiocarpa. The cytotoxicity of these compounds to various tumor cell lines was evaluated, and compound 15 significantly suppressed growth of HeLa, Vero, K562, Raji, Wish, and Calu-1 tumor cell lines. With the exception of K562 cells, the proliferation of other tumor cell lines was inhibited by compounds 3 and 10.
Authors:
L C Lin; C J Chou; Y C Kuo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  64     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-25     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  674-6     Citation Subset:  IM    
Affiliation:
National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, Republic of China. lclin@cma23.nricm.edu.tw
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / chemistry,  isolation & purification
Antineoplastic Agents, Phytogenic / chemistry*,  isolation & purification,  pharmacology*
Chromatography, High Pressure Liquid
Drug Screening Assays, Antitumor
Flavonoids / chemistry*,  isolation & purification,  pharmacology*
Humans
Magnetic Resonance Spectroscopy
Optical Rotation
Plant Extracts / chemistry
Plants, Medicinal / chemistry*
Spectrophotometry, Ultraviolet
Taiwan
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Antineoplastic Agents, Phytogenic; 0/Flavonoids; 0/Plant Extracts; 480-20-6/aromadedrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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