| Cytotoxic principles from Ventilago leiocarpa. | |
| | |
MedLine Citation:
|
PMID: 11374975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Three new anthraquinones, islandicin 4-methyl ether (1), 1,2,6-trihydroxy-7,8-dimethoxy-3-methylanthraquinone (2), and 2-hydroxyemodin 1-methyl ether (3) as well as two known triterpenoids [taraxerol (4), lupeol (5)], six anthraquinones [chrysophanol (6), islandicin (8), parietin (9), emodin (10), catenarin (11), skyrin (15)], a 2,3-dihydroflavonol [(+)-aromadendrin (12)], two benzisochromanquinones [ventiloquinone K (13) and ventiloquinone I (14)], and stigmasterol (7) were isolated from Ventilago leiocarpa. The cytotoxicity of these compounds to various tumor cell lines was evaluated, and compound 15 significantly suppressed growth of HeLa, Vero, K562, Raji, Wish, and Calu-1 tumor cell lines. With the exception of K562 cells, the proliferation of other tumor cell lines was inhibited by compounds 3 and 10. |
| | |
Authors:
|
L C Lin; C J Chou; Y C Kuo |
Related Documents
:
|
19358565 - Brartemicin, an inhibitor of tumor cell invasion from the actinomycete nonomuraea sp. 20061445 - Pharmacology and antitumor activity of abc294640, a selective inhibitor of sphingosine ... 15497935 - Additional cytotoxic sterols and saponins from the starfish certonardoa semiregularis. 21064045 - Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillid... 6704905 - Granular cell tumor of the intrapancreatic common bile duct. 12457715 - Management of sarcomas of the head and neck in adults. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of natural products Volume: 64 ISSN: 0163-3864 ISO Abbreviation: J. Nat. Prod. Publication Date: 2001 May |
Date Detail:
|
Created Date: 2001-05-25 Completed Date: 2001-09-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
|
Languages: eng Pagination: 674-6 Citation Subset: IM |
Affiliation:
|
National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, Republic of China. lclin@cma23.nricm.edu.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkaloids
/
chemistry,
isolation & purification Antineoplastic Agents, Phytogenic / chemistry*, isolation & purification, pharmacology* Chromatography, High Pressure Liquid Drug Screening Assays, Antitumor Flavonoids / chemistry*, isolation & purification, pharmacology* Humans Magnetic Resonance Spectroscopy Optical Rotation Plant Extracts / chemistry Plants, Medicinal / chemistry* Spectrophotometry, Ultraviolet Taiwan Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
|
0/Alkaloids; 0/Antineoplastic Agents, Phytogenic; 0/Flavonoids; 0/Plant Extracts; 480-20-6/aromadedrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiprotozoal activity of the constituents of Conyza filaginoides.
Next Document: Brachycerine, a novel monoterpene indole alkaloid from Psychotria brachyceras.