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Cytotoxic potential of Indian spices (extracts) against esophageal squamous carcinoma cells.
MedLine Citation:
PMID:  22292653     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Diet is one of the important factors in cancer etiology and prevention. The Indian diet is particularly interesting in its many unique dietary constituents, including spices like chili pepper, cloves, black pepper and black cumin, that have promise as chemopreventive agents. The objective of the present study was to compare the in vitro anticancer activities of aqueous and ethanolic extracts against the TE-13 (esophageal squamous cell carcinoma) cell line. All extracts showed cytotoxic activity but aqueous extracts were found to be more potent than alcoholic extracts. Morphological analysis, DAPI staining and DNA fragmentation assays showed maximum cell death and apoptotic cell demise (88%) to occur within 24 hours with an aqueous extract of chili pepper at 300μl/ml.
Authors:
Vinay Dwivedi; Richa Shrivastava; Showket Hussain; Chaiti Ganguly; Mausumi Bharadwaj
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of cancer prevention : APJCP     Volume:  12     ISSN:  1513-7368     ISO Abbreviation:  Asian Pac. J. Cancer Prev.     Publication Date:  2011  
Date Detail:
Created Date:  2012-02-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130625     Medline TA:  Asian Pac J Cancer Prev     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  2069-73     Citation Subset:  IM    
Affiliation:
Division of Molecular Genetics and Biochemistry, Inst. of Cytology and Preventive Oncology (ICMR), India E-mail mausumi.bharadwaj@gmail.com.
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