| Cytotoxic potential of Indian spices (extracts) against esophageal squamous carcinoma cells. | |
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MedLine Citation:
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PMID: 22292653 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Diet is one of the important factors in cancer etiology and prevention. The Indian diet is particularly interesting in its many unique dietary constituents, including spices like chili pepper, cloves, black pepper and black cumin, that have promise as chemopreventive agents. The objective of the present study was to compare the in vitro anticancer activities of aqueous and ethanolic extracts against the TE-13 (esophageal squamous cell carcinoma) cell line. All extracts showed cytotoxic activity but aqueous extracts were found to be more potent than alcoholic extracts. Morphological analysis, DAPI staining and DNA fragmentation assays showed maximum cell death and apoptotic cell demise (88%) to occur within 24 hours with an aqueous extract of chili pepper at 300μl/ml. |
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Authors:
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Vinay Dwivedi; Richa Shrivastava; Showket Hussain; Chaiti Ganguly; Mausumi Bharadwaj |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of cancer prevention : APJCP Volume: 12 ISSN: 1513-7368 ISO Abbreviation: Asian Pac. J. Cancer Prev. Publication Date: 2011 |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130625 Medline TA: Asian Pac J Cancer Prev Country: Thailand |
Other Details:
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Languages: eng Pagination: 2069-73 Citation Subset: IM |
Affiliation:
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Division of Molecular Genetics and Biochemistry, Inst. of Cytology and Preventive Oncology (ICMR), India E-mail mausumi.bharadwaj@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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