| Cytotoxic platinum(ii) intercalators that incorporate 1R,2R-diaminocyclopentane. | |
| | |
MedLine Citation:
|
PMID: 23018340 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Twelve metallointercalators of the type [Pt(I(L))(A(L))](2+), where A(L) is either the R,R or S,S enantiomer of 1,2-diaminocyclopentane (DACP) and I(L) is either 1,10-phenathroline, 4-methyl-1,10-phenanthroline, 5-methyl-1,10-phenanthroline, 4,7-dimethyl-1,10-phenanthroline, 5,6-dimethyl-1,10-phenanthroline or 3,4,7,8-tetramethyl-1,10-phenanthroline, were synthesised, characterised and the cytotoxicity to the L1210 cell line was determined. The crystal structures of PHENRRDACP and PHENSS were obtained as monoclinic with a space group of P2(1) (a/Å = 11.4966, b/Å = 6.6983, c/Å = 12.0235) and P2(1) (a/Å = 11.5777, b/Å = 7.0009, c/Å = 12.5079), respectively. The R,R enantiomer of 1,2-diaminocyclopentane (RRDACP) produced the most cytotoxic metallointercalators. The most cytotoxic metallointercalators were 56MERRDACP and 47MERRDACP with IC(50) values of 0.16 and 0.17 μM, respectively, in comparison to cisplatin (1 μM). |
| | |
Authors:
|
K Benjamin Garbutcheon-Singh; Peter Leverett; Simon Myers; Janice R Aldrich-Wright |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-28 |
Journal Detail:
|
Title: Dalton transactions (Cambridge, England : 2003) Volume: - ISSN: 1477-9234 ISO Abbreviation: Dalton Trans Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101176026 Medline TA: Dalton Trans Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Nanoscale Organisation and Dynamics Group, School of Science and Health, University of Western Sydney, Locked Bag 1797, Penrith South DC, NSW 2751, Australia. j.aldrich-wright@uws.edu.au. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Do research activities during college, medical school, and residency mediate racial/ethnic dispariti...
Next Document: Evaluation of removable statistical interaction for binary traits.