Document Detail


Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.
MedLine Citation:
PMID:  12560036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.
Authors:
Lie-Chwen Lin; Ling-Ling Yang; Cheng-Jen Chou
Related Documents :
23940516 - Radiation therapy-induced tumor invasiveness is associated with sdf-1-regulated macroph...
15938136 - Cytotoxic lignans from the stems of styrax camporum (styracaceae).
17118336 - Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian dna polymeras...
23340716 - Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuc...
16827806 - Genetically engineered bifidobacterium longum for tumor-targeting enzyme-prodrug therap...
21373386 - Hepatocellular carcinoma with foamy histiocyte-like appearance: a deceptively clear cel...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytochemistry     Volume:  62     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  619-22     Citation Subset:  IM    
Affiliation:
National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, ROC. lclin@cma23.nricm.edu.tw
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology
Cell Survival / drug effects
Coumarins / chemistry*
Glucosides / chemistry,  isolation & purification*,  pharmacology
Hydrolysis
Inhibitory Concentration 50
Keto Acids / chemistry*
Magnetic Resonance Spectroscopy
Molecular Structure
Naphthoquinones / chemistry,  isolation & purification*,  pharmacology
Plant Roots / chemistry
Plumbaginaceae / chemistry*
Taiwan
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Coumarins; 0/Glucosides; 0/Keto Acids; 0/Naphthoquinones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prenylated xanthone glucosides from Ural's lichen Umbilicaria proboscidea.
Next Document:  Indolomonoterpenic alkaloids from Strychnos icaja roots.