Document Detail


Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.
MedLine Citation:
PMID:  12560036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.
Authors:
Lie-Chwen Lin; Ling-Ling Yang; Cheng-Jen Chou
Related Documents :
23849696 - Inhibition of hsp27 radiosensitizes head-and-neck cancer by modulating deoxyribonucleic...
23381546 - Role of enolase-1 in response to hypoxia in breast cancer: exploring the mechanisms of ...
16819196 - Growth inhibition of stilbenoids in welwitschiaceae and gnetaceae through induction of ...
3549036 - Biological and biochemical properties of new anticancer folate antagonists.
22728546 - Enhanced anticancer activity of gemcitabine coupling with conjugated linoleic acid agai...
15729726 - Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow-...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytochemistry     Volume:  62     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  619-22     Citation Subset:  IM    
Affiliation:
National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, ROC. lclin@cma23.nricm.edu.tw
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology
Cell Survival / drug effects
Coumarins / chemistry*
Glucosides / chemistry,  isolation & purification*,  pharmacology
Hydrolysis
Inhibitory Concentration 50
Keto Acids / chemistry*
Magnetic Resonance Spectroscopy
Molecular Structure
Naphthoquinones / chemistry,  isolation & purification*,  pharmacology
Plant Roots / chemistry
Plumbaginaceae / chemistry*
Taiwan
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Coumarins; 0/Glucosides; 0/Keto Acids; 0/Naphthoquinones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prenylated xanthone glucosides from Ural's lichen Umbilicaria proboscidea.
Next Document:  Indolomonoterpenic alkaloids from Strychnos icaja roots.