Document Detail

Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.
MedLine Citation:
PMID:  12560036     Owner:  NLM     Status:  MEDLINE    
Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.
Lie-Chwen Lin; Ling-Ling Yang; Cheng-Jen Chou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytochemistry     Volume:  62     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  619-22     Citation Subset:  IM    
National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, ROC.
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MeSH Terms
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology
Cell Survival / drug effects
Coumarins / chemistry*
Glucosides / chemistry,  isolation & purification*,  pharmacology
Inhibitory Concentration 50
Keto Acids / chemistry*
Magnetic Resonance Spectroscopy
Molecular Structure
Naphthoquinones / chemistry,  isolation & purification*,  pharmacology
Plant Roots / chemistry
Plumbaginaceae / chemistry*
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Coumarins; 0/Glucosides; 0/Keto Acids; 0/Naphthoquinones

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