| Cytotoxic mechanisms may play a role in the local immune response in the central nervous system in neuroborreliosis. | |
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MedLine Citation:
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PMID: 21056912 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aiming to investigate the role of cytotoxic mechanisms in neuroborreliosis (NB), the cytokines IL-2, IL-7, IL-10, IL-12p70, IL-15, GM-CSF and the Th17-cytokine IL-17 were analyzed in cerebrospinal fluid (CSF) and plasma from NB-patients. NB-patients showed increased levels in CSF compared to controls of all analyzed cytokines except IL-15 but not in plasma. Blood lymphocytes from three NB-patients showed functional cytotoxicity in response to autologous Borrelia-infected macrophages. The findings support a role for cytotoxic mechanisms in the local immune response in NB and in addition suggest an increase of IL-17. |
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Authors:
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Marika Nordberg; Pia Forsberg; Anna Johansson; Dag Nyman; Christian Jansson; Jan Ernerudh; Christina Ekerfelt |
Publication Detail:
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Type: Journal Article Date: 2010-11-05 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 232 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 186-93 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Linköping University, Dept. of Clinical and Experimental Medicine, Division of Infectious Medicine, Linköping, Sweden; Åland Borrelia group, Åland Central Hospital, Mariehamn, Åland, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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