| Cytotoxic gold(i)-bearing dendrimers from alkyne precursors. | |
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MedLine Citation:
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PMID: 21761078 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A series of four dendrimers end-functionalized with gold(i) has been prepared from alkyne-terminated precursors and (tricyclohexylphosphine)gold(i) azide. Isolated yields range from 84-89%, based on gold. The first-generation dendrimer is cytotoxic toward 3T3 mouse fibroblast cells. Apoptosis ensues within 6 h of treatment with gold(i). |
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Authors:
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Thomas J Robilotto; Daniel S Alt; Horst A von Recum; Thomas G Gray |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-15 |
Journal Detail:
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Title: Dalton transactions (Cambridge, England : 2003) Volume: - ISSN: 1477-9234 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101176026 Medline TA: Dalton Trans Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, USA. tgray@case.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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