Document Detail

Cytotoxic evaluation of semisynthetic ester and amide derivatives of oleanolic acid.
MedLine Citation:
PMID:  21121249     Owner:  NLM     Status:  MEDLINE    
Although a number of chemicals have been isolated from Lantana camara, only a few have been evaluated for their biological significance. As part of our drug discovery program for cytotoxic agents from Indian medicinal plants, roots of L. camara L. were chemically investigated, which resulted in the isolation and identification of a cytotoxic agent, oleanolic acid (1b) as a major constituent. Oleanolic acid was converted into six semi-synthetic ester (2-7) and seven amide (8-14) derivatives. The ester derivatives (2-7) showed 3-6 times more selective activity than 1b against the human ovarian cancer cell line (IGR-OV-1), while amide derivatives 8-14 showed 16-53 times more selective activity against the human lung cancer cell line (HOP-62). Structure activity relationship within the ester (2-7) and amide (8-14) derivatives are discussed.
Shikha Gupta; Komal Kalani; Mohit Saxena; Santosh K Srivastava; Satyam K Agrawal; Nitasha Suri; Ajit K Saxena
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product communications     Volume:  5     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-12-02     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1567-70     Citation Subset:  IM    
Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow-226015, India.
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MeSH Terms
Amides / chemistry
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*
Cell Line, Tumor
Drug Evaluation, Preclinical
Esters / chemistry
Lantana / chemistry*
Oleanolic Acid / analogs & derivatives*
Structure-Activity Relationship
Reg. No./Substance:
0/Amides; 0/Antineoplastic Agents, Phytogenic; 0/Esters; 508-02-1/Oleanolic Acid

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