| Cytotoxic evaluation of sarcodifurines A and B, two novel dihydrofuroquinolines from Sarcomelicope follicularis (Rutaceae). | |
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MedLine Citation:
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PMID: 18608759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sarcodifurines A and B are two original dihydrofuroquinolines isolated from Sarcomelicope follicularis, a New Caledonian tree. The cytotoxicity and antiproliferative activity of these two alkaloids were investigated against 8 distinct cell lines representative of the most frequent solid tumors developing in human. Cytotoxicity of sarcodifurines was low on the 8 cell lines, with, for example, less than 10% of the total cells killed after 24 h exposure at 10 microM and IC(50) approximately 7.10(-5) M (MCF-7 and MDA MB 231 cell lines). Proliferation studies confirmed that sarcodifurines had a weak effect on cancer cells growth, with less than 5% growth inhibition at 10 microM. Sarcodifurine A activity was comparable to that of Sarcodifurine B, in term of cytotoxicity and antiproliferative activity on all cell lines. In spite of the weak activity of sarcodifurines and furoquinolines, rationalized pharmacomodulations to obtain planar analogs could lead to efficient topoisomerases inhibitors and DNA intercalants. |
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Authors:
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Elizabeth Chosson; Christiane Guguen-Guillouzo; Denise Glaise; Laurent Picot; Elisabeth Seguin; Thierry Besson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of enzyme inhibition and medicinal chemistry Volume: 23 ISSN: 1475-6374 ISO Abbreviation: J Enzyme Inhib Med Chem Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-29 Completed Date: 2008-12-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101150203 Medline TA: J Enzyme Inhib Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 704-7 Citation Subset: IM |
Affiliation:
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Université de Rouen, CNRS UMR 6014, C.O.B.R.A. - I.R.C.O.F., UFR Méédecine-Pharmacie, Rouen Cedex 1, France. elizabeth.chosson@univ-rouen.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Death
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drug effects Cell Line, Tumor Cell Proliferation / drug effects DNA Topoisomerases / antagonists & inhibitors Furans / isolation & purification, pharmacology* Humans Intercalating Agents Quinolines / isolation & purification, pharmacology* Rutaceae / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Furans; 0/Intercalating Agents; 0/Quinolines; 0/sarcodifurine A; 0/sarcodifurine B; EC 5.99.1.-/DNA Topoisomerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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