| Cytotoxic evaluation of phenolic compounds from lichens against melanoma cells. | |
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MedLine Citation:
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PMID: 23207680 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Atranorin, lichexanthone, and the (+)-usnic, diffractaic, divaricatic, perlatolic, psoromic, protocetraric, and norstictic acids isolated from the lichens Parmotrema dilatatum (Vain.) Hale, Usnea subcavata Motyka, Usnea sp., Ramalina sp., Cladina confusa (Sant.) Folmm. & Ahti, Dirinaria aspera Häsänen, and Parmotrema lichexanthonicum Eliasaro & Adler were evaluated against UACC-62 and B16-F10 melanoma cells and 3T3 normal cells. SRB assay revealed significant cytotoxic activity in protocetraric, divaricatic, and perlatolic acids on UACC-62 cells (GI(50) 0.52, 2.7, and 3.3 μg/mL, respectively). Divaricatic and perlatolic acids proved the most active on B16-F10 cells (GI(50) 4.4 and 18.0 μg/mL, respectively) and the most cytotoxic to 3T3 normal cells. Diffractaic, usnic, norstictic, and psoromic acids were cytotoxic to UACC-62 cells in the 24.7 to 36.6 μg/mL range, as were protocetraric and diffractaic acids to B16-F10 cells (GI(50) 24.0 and 25.4 μg/mL, respectively). Protocetraric acid was highly selective (SI* 93.3) against UACC-62 cells, followed by norstictic, perlatolic, psoromic, and divaricatic acids, while norstictic and divaricatic acids were more selective against B16-F10 cells. The high SI* value obtained for protocetraric acid on UACC-62 cells makes it a potential candidate for the study of melanomas in experimental models. Chemometric analysis was performed to evaluate the general behavior of the compounds against the cell lines tested. |
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Authors:
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Luiz Fabrício Gardini Brandão; Glaucia Braz Alcantara; Maria de Fátima Cepa Matos; Danielle Bogo; Deisy Dos Santos Freitas; Nathália Mitsuko Oyama; Neli Kika Honda |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-03 |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: - ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, Universidade Federal de Mato Grosso do Sul. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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