Document Detail

Cytotoxic evaluation of phenolic compounds from lichens against melanoma cells.
MedLine Citation:
PMID:  23207680     Owner:  NLM     Status:  Publisher    
Atranorin, lichexanthone, and the (+)-usnic, diffractaic, divaricatic, perlatolic, psoromic, protocetraric, and norstictic acids isolated from the lichens Parmotrema dilatatum (Vain.) Hale, Usnea subcavata Motyka, Usnea sp., Ramalina sp., Cladina confusa (Sant.) Folmm. & Ahti, Dirinaria aspera Häsänen, and Parmotrema lichexanthonicum Eliasaro & Adler were evaluated against UACC-62 and B16-F10 melanoma cells and 3T3 normal cells. SRB assay revealed significant cytotoxic activity in protocetraric, divaricatic, and perlatolic acids on UACC-62 cells (GI(50) 0.52, 2.7, and 3.3 μg/mL, respectively). Divaricatic and perlatolic acids proved the most active on B16-F10 cells (GI(50) 4.4 and 18.0 μg/mL, respectively) and the most cytotoxic to 3T3 normal cells. Diffractaic, usnic, norstictic, and psoromic acids were cytotoxic to UACC-62 cells in the 24.7 to 36.6 μg/mL range, as were protocetraric and diffractaic acids to B16-F10 cells (GI(50) 24.0 and 25.4 μg/mL, respectively). Protocetraric acid was highly selective (SI* 93.3) against UACC-62 cells, followed by norstictic, perlatolic, psoromic, and divaricatic acids, while norstictic and divaricatic acids were more selective against B16-F10 cells. The high SI* value obtained for protocetraric acid on UACC-62 cells makes it a potential candidate for the study of melanomas in experimental models. Chemometric analysis was performed to evaluate the general behavior of the compounds against the cell lines tested.
Luiz Fabrício Gardini Brandão; Glaucia Braz Alcantara; Maria de Fátima Cepa Matos; Danielle Bogo; Deisy Dos Santos Freitas; Nathália Mitsuko Oyama; Neli Kika Honda
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-03
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  -     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry, Universidade Federal de Mato Grosso do Sul.
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