| Cytotoxic effects of two organotin compounds and their mode of inflicting cell death on four mammalian cancer cells. | |
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MedLine Citation:
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PMID: 21069563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this report, we have tested the cytotoxicity of two organotin (OT) compounds by flow cytometry on a panel of immortalized cancer cell lines of human and murine origin. Although the OT compounds exhibited varying levels of cytotoxicity, diphenylmethyltin chloride was more toxic than 1,4-bis (diphenylchlorostannyl)p-xylene on all cell lines tested. The OT compounds were found to be highly cytotoxic to lymphoma cell lines with lower toxicity toward the HeLa cervical cancer cell line. In order to discern the mechanism by which cell death was induced, additional experiments were conducted to monitor characteristic changes consistent with apoptosis and/or necrosis. Cell lines treated with the experimental compounds indicated that there was no consistent mode of cell death induction. However, both compounds induced apoptosis in the pro-B lymphocyte cell line, NFS-70. The work presented here also demonstrates that the two OT compounds possess selective cytotoxicity against distinct transformed cell lines. |
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Authors:
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Armando Varela-Ramirez; Margaret Costanzo; Yazmin P Carrasco; Keith H Pannell; Renato J Aguilera |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-31 |
Journal Detail:
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Title: Cell biology and toxicology Volume: 27 ISSN: 1573-6822 ISO Abbreviation: Cell Biol. Toxicol. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-08-16 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 8506639 Medline TA: Cell Biol Toxicol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 159-68 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Biosciences Research Building, University of Texas at El Paso, El Paso, TX 79968-5816, USA. avarela2@utep.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Annexin A5 / metabolism Antineoplastic Agents / pharmacology*, toxicity Apoptosis / drug effects* Cell Line, Tumor Drug Screening Assays, Antitumor Flow Cytometry Humans Inhibitory Concentration 50 Intercalating Agents Mice Necrosis Organotin Compounds / pharmacology*, toxicity Propidium Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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5G12RR008124/RR/NCRR NIH HHS; 5T34GM008048-25/GM/NIGMS NIH HHS; G12 RR008124-15S1/RR/NCRR NIH HHS; G12 RR008124-18/RR/NCRR NIH HHS; R25 GM069621-07/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/1,4-bis(diphenylchlorostannyl)-p-xylene; 0/Annexin A5; 0/Antineoplastic Agents; 0/Intercalating Agents; 0/Organotin Compounds; 0/diphenylmethyltin chloride; 36015-30-2/Propidium |
| Comments/Corrections | |
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