Document Detail

Cytotoxic effects of two organotin compounds and their mode of inflicting cell death on four mammalian cancer cells.
MedLine Citation:
PMID:  21069563     Owner:  NLM     Status:  MEDLINE    
In this report, we have tested the cytotoxicity of two organotin (OT) compounds by flow cytometry on a panel of immortalized cancer cell lines of human and murine origin. Although the OT compounds exhibited varying levels of cytotoxicity, diphenylmethyltin chloride was more toxic than 1,4-bis (diphenylchlorostannyl)p-xylene on all cell lines tested. The OT compounds were found to be highly cytotoxic to lymphoma cell lines with lower toxicity toward the HeLa cervical cancer cell line. In order to discern the mechanism by which cell death was induced, additional experiments were conducted to monitor characteristic changes consistent with apoptosis and/or necrosis. Cell lines treated with the experimental compounds indicated that there was no consistent mode of cell death induction. However, both compounds induced apoptosis in the pro-B lymphocyte cell line, NFS-70. The work presented here also demonstrates that the two OT compounds possess selective cytotoxicity against distinct transformed cell lines.
Armando Varela-Ramirez; Margaret Costanzo; Yazmin P Carrasco; Keith H Pannell; Renato J Aguilera
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-31
Journal Detail:
Title:  Cell biology and toxicology     Volume:  27     ISSN:  1573-6822     ISO Abbreviation:  Cell Biol. Toxicol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-16     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8506639     Medline TA:  Cell Biol Toxicol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-68     Citation Subset:  IM    
Department of Biological Sciences, Biosciences Research Building, University of Texas at El Paso, El Paso, TX 79968-5816, USA.
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MeSH Terms
Annexin A5 / metabolism
Antineoplastic Agents / pharmacology*,  toxicity
Apoptosis / drug effects*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Flow Cytometry
Inhibitory Concentration 50
Intercalating Agents
Organotin Compounds / pharmacology*,  toxicity
Structure-Activity Relationship
Grant Support
5G12RR008124/RR/NCRR NIH HHS; 5T34GM008048-25/GM/NIGMS NIH HHS; G12 RR008124-15S1/RR/NCRR NIH HHS; G12 RR008124-18/RR/NCRR NIH HHS; R25 GM069621-07/GM/NIGMS NIH HHS
Reg. No./Substance:
0/1,4-bis(diphenylchlorostannyl)-p-xylene; 0/Annexin A5; 0/Antineoplastic Agents; 0/Intercalating Agents; 0/Organotin Compounds; 0/diphenylmethyltin chloride; 36015-30-2/Propidium

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