| Cytotoxic effects of flavonoids against a human colon cancer derived cell line, COLO 201: a potential natural anti-cancer substance. | |
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MedLine Citation:
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PMID: 19070422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The proliferation of a human colon carcinoma cell line, COLO 201, was effectively suppressed through apoptosis in the presence of flavonoids, an ethanol extract from Vitex agnus-castus fruits. The induction of apoptosis was not inhibited by the presence of an anti-oxidant, N-acetyl-L-cysteine, whereas only HO-1 gene expression levels increased among other typical oxidative stress-associated genes examined after Vitex treatment. These results suggest that Vitex treatment activates a pathway associated with HO-1 gene activation, resulting in the induction of apoptosis in COLO 201. Results also implicate a potential clinical chemotherapeutic application of Vitex for the treatment of colon cancer patients. |
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Authors:
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Masahiko Imai; Hidetomo Kikuchi; Takanori Denda; Kunio Ohyama; Chieko Hirobe; Hiroo Toyoda |
Publication Detail:
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Type: Journal Article Date: 2008-12-12 |
Journal Detail:
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Title: Cancer letters Volume: 276 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-02-23 Completed Date: 2009-03-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 74-80 Citation Subset: IM |
Affiliation:
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Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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pharmacology Antineoplastic Agents, Phytogenic / pharmacology* Antioxidants / pharmacology Apoptosis / drug effects Cell Line, Tumor Colonic Neoplasms / drug therapy* DNA Fragmentation / drug effects Flavonoids / pharmacology* Free Radical Scavengers / pharmacology Fruit* / chemistry Gene Expression / drug effects Heme Oxygenase-1 / biosynthesis, drug effects, genetics Humans Luteolin / pharmacology Phytotherapy* Plant Extracts / pharmacology Reverse Transcriptase Polymerase Chain Reaction Vitex / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Antioxidants; 0/Flavonoids; 0/Free Radical Scavengers; 0/Plant Extracts; 491-70-3/Luteolin; 616-91-1/Acetylcysteine; EC 1.14.99.3/HMOX1 protein, human; EC 1.14.99.3/Heme Oxygenase-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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