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Cytotoxic effects of the compound cis-tetraammine(oxalato)ruthenium(III) dithionate on K-562 human chronic myelogenous leukemia cells.
MedLine Citation:
PMID:  25019046     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Chemotherapy is a common treatment for leukemia. Ruthenium complexes have shown potential utility in chemotherapy and photodynamic therapy. The identification of new chemotherapeutics agents is critical for further progress in the treatment of leukemia. Ruthenium complexes generally have lower toxicities compared to cisplatin attributed to their specific accumulation in cancer tissues. Based on these evidences, in the present work we studied the cytotoxic activity of the ruthenium(III) compound cis-tetraammine(oxalato)ruthenium(III) dithionate - {cis-[Ru(C2O4)(NH3)4]2(S2O6)} against human chronic myelogenous leukemia cells (K-562) tumor cell line. The tested compound induces cell death in a dose and time dependent manner on K-562 cells. It is found that the effect was improved linearly while prolonging the incubation time. Compared to the cell cycle profiles of untreated cells, flow cytometric analysis indicated the sub-G1 arresting effect of ruthenium compound on K-562 cells. In our study, {cis-[Ru(C2O4)(NH3)4]2(S2O6)} shows a significant increase in tailed cells in any of the concentrations tested compared with negative control. Consequently, the concentration of {cis-[Ru(C2O4)(NH3)4]2(S2O6)} might be associated cytotoxicity with direct effect on K-562 cells DNA. Thus, it can be deducted that ruthenium-based compounds present selectivity to enter both tumor and normal cells. Additional studies are needed to determine the molecular mechanisms of the active components and to evaluate the potential in vivo anticancer activity of the cis-tetraammine(oxalato)ruthenium(III) dithionate.
Authors:
Flávia de Castro Pereira; Aliny Pereira de Lima; Cesar Augusto Sam Tiago Vilanova-Costa; Wanessa Carvalho Pires; Alessandra de Santana Braga Barbosa Ribeiro; Lucas Carlos Gomes Pereira; Luiz Alfredo Pavanin; Wagner Batista Dos Santos; Elisângela de Paula Silveira-Lacerda
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Publication Detail:
Type:  Journal Article     Date:  2014-06-19
Journal Detail:
Title:  SpringerPlus     Volume:  3     ISSN:  2193-1801     ISO Abbreviation:  Springerplus     Publication Date:  2014  
Date Detail:
Created Date:  2014-07-14     Completed Date:  2014-07-14     Revised Date:  2014-07-17    
Medline Journal Info:
Nlm Unique ID:  101597967     Medline TA:  Springerplus     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  301     Citation Subset:  -    
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