Document Detail


Cytotoxic effect of palytoxin on mussel.
MedLine Citation:
PMID:  20206198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Palytoxin is a large and complex polyhydroxylated molecule with potent neurotoxic activity. Dinoflagellates from the Ostreopsis genera were demonstrated to be producers of this compound and analogues. Even though initially palytoxin appearance was restricted to tropical areas, the recent occurrence of Ostreopsis outbreaks in Mediterranean Sea point to a worldwide dissemination probably related to climatic change. Those dinoflagellates can bioaccumulate in shellfish, especially in filter-feeding mollusks and have been involved in damaging effects in seafood or human toxic outbreaks. The present study describes palytoxins effect on metabolic activity of mantle and hepatopancreas cells from the mussel Mytilus galloprovincialis Lmk. Our results indicate that palytoxin is highly cytotoxic to mussel cells; unlike it happens with other toxins more common in European coasts such as okadaic acid and azaspiracid. These findings have a special significance for the marine environment and aquiculture since they are evidence for the ability of palytoxin to affect the integrity of bivalve mollusks that are not adapted to the presence of this toxin.
Authors:
M Carmen Louzao; Begoña Espiña; Eva Cagide; Isabel R Ares; Amparo Alfonso; Mercedes R Vieytes; Luis M Botana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-03
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  56     ISSN:  1879-3150     ISO Abbreviation:  Toxicon     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  842-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain.
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MeSH Terms
Descriptor/Qualifier:
Acrylamides / toxicity*
Animals
Bivalvia / drug effects*,  parasitology
Dinoflagellida / isolation & purification
Chemical
Reg. No./Substance:
0/Acrylamides; 11077-03-5/palytoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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