Document Detail

Cytotoxic effect of orthodontic appliances.
MedLine Citation:
PMID:  1563474     Owner:  NLM     Status:  MEDLINE    
The use of orthodontic appliances may contribute to local gingivitis, often attributed to increased plaque retention. Gingivitis of bacterial origin cannot clinically be distinguished from local tissue irritation caused by corrosion products. The purpose of this investigation was to assess the cytotoxic effect of various metallic components used in orthodontics. Multicomponent devices such as facebows, molar bands, and brackets along with single-component brackets and archwires were tested by the agar overlay cytotoxicity test with mouse fibroblast cells. None of the archwires caused any cytotoxic effect, even though some contained 54 per cent nickel. However, the multi-component devices, which were joined with silver- and copper-based brazing alloys were more cytotoxic than the single-component devices. Copper is more cytotoxic than nickel, which could explain the greater cytotoxic effect of the samples with brazing materials. It is speculated that cytotoxic corrosion products from orthodontic appliances might contribute to localized gingivitis.
M R Grimsdottir; A Hensten-Pettersen; A Kullmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of orthodontics     Volume:  14     ISSN:  0141-5387     ISO Abbreviation:  Eur J Orthod     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-19     Completed Date:  1992-05-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7909010     Medline TA:  Eur J Orthod     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  D; IM    
NIOM, Scandinavian Institute of Dental Materials, University of Oslo, Norway.
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MeSH Terms
Biocompatible Materials / chemistry*
Cell Survival
Cells, Cultured
Chromium Alloys / chemistry
Copper / chemistry
Dental Alloys / chemistry*
Extraoral Traction Appliances
Fibroblasts / pathology
Iron / chemistry
Manganese / chemistry
Nickel / chemistry
Orthodontic Appliances*
Orthodontic Brackets
Orthodontic Wires
Silver / chemistry
Titanium / chemistry
Zinc / chemistry
Reg. No./Substance:
0/Biocompatible Materials; 0/Chromium Alloys; 0/Dental Alloys; 12035-60-8/titanium nickelide; 7439-89-6/Iron; 7439-96-5/Manganese; 7440-02-0/Nickel; 7440-22-4/Silver; 7440-32-6/Titanium; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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