Document Detail


CYTOTOXIC EFFECT OF MYCOBACTERIA ON EHRLICH ASCITES CELLS.
MedLine Citation:
PMID:  14255665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bekierkunst, Adam (Bryn Mawr College, Bryn Mawr, Pa.), and L. Joe Berry. Cytotoxic effect of mycobacteria on Ehrlich ascites cells. J. Bacteriol. 89:205-211. 1965.-Mycobacterium tuberculosis, strains H(37)Rv, H(37)Ra, and BCG, release into a medium within 3 to 5 hr a substance that is toxic to Ehrlich ascites cells as evidenced by a diminished packed cell volume after 5 to 7 days of growth in the peritoneal cavity of mice. Cell-free extracts of the above strains of mycobacteria display the same type of cytotoxic effect, the strongest action being that of the virulent strain, H(37)Rv. The nicotinamide adenine dinucleotidase activity of surviving tumor cells was three to four times greater after treatment with the mycobacterial extracts than that of control cells. The cycotoxicity is probably due to cord factor, because 10 mug of this substance injected intraperitoneally into mice bearing Ehrlich ascites cells inhibited the growth of the cells to 50% of that of control cells. An increase in nicotinamide adenine dinucleotidase activity was found in surviving tumor cells after cord factor treatment.
Authors:
A BEKIERKUNST; L J BERRY
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  89     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1965 Jan 
Date Detail:
Created Date:  1965-05-01     Completed Date:  1996-12-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Ehrlich Tumor*
Mice*
Mycobacterium tuberculosis*
Nucleotidases*
Phagocytosis*
Research*
Chemical
Reg. No./Substance:
EC 3.1.3.-/Nucleotidases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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