Document Detail

Cytotoxic effect of four root filling materials.
MedLine Citation:
PMID:  11202896     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the cytotoxic effect of four root canal sealers: AH26, AH Plus, Diaket and Apexit. In the experiment two cell lines, human cervical carcinoma (HeLa) cells and mouse skin fibroblasts (L929), were used. Under aseptic conditions, the sealers were prepared according to the manufacturers' directions, and 0.01 mL of each material was placed in a 24-well plate. The sealers were covered with cell suspension. The cytotoxicity was estimated by determining the number of viable cells by a light microscope, as well as the total number of cells 24 h, 48 h and 120 h after the treatment with mentioned materials. The results obtained in this study showed the high cytotoxcity of the new AH Plus root canal sealer, which was shown to be equally or more toxic to the standard AH26 and Diaket materials. Apexit was the least toxic sealer.
I Miletić; I Anić; Z Karlović; T Marsan; S Pezelj-Ribarić; M Osmak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endodontics & dental traumatology     Volume:  16     ISSN:  0109-2502     ISO Abbreviation:  Endod Dent Traumatol     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-03-15     Revised Date:  2012-03-05    
Medline Journal Info:
Nlm Unique ID:  8508054     Medline TA:  Endod Dent Traumatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  287-90     Citation Subset:  D    
Department of Dental Pathology, School of Dentistry, University of Zagreb, Zagreb, Croatia.
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MeSH Terms
Bismuth / toxicity
Calcium Hydroxide / toxicity
Cell Count
Cell Line
Cell Size / drug effects
Cell Survival / drug effects
Drug Combinations
Epoxy Resins / toxicity
Fibroblasts / drug effects
HeLa Cells / drug effects
Methenamine / toxicity
Polyvinyls / toxicity
Root Canal Filling Materials / toxicity*
Silver / toxicity
Skin / cytology,  drug effects
Statistics as Topic
Time Factors
Titanium / toxicity
Tumor Cells, Cultured
Zinc Oxide / toxicity
Reg. No./Substance:
0/Apexit; 0/Drug Combinations; 0/Epoxy Resins; 0/Polyvinyls; 0/Root Canal Filling Materials; 0/expoy resin-based root canal sealer; 100-97-0/Methenamine; 1305-62-0/Calcium Hydroxide; 1314-13-2/Zinc Oxide; 55599-25-2/epoxy resin AH-26; 56509-77-4/Diaket; 7440-22-4/Silver; 7440-32-6/Titanium; 7440-69-9/Bismuth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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