| Cytotoxic crossmatch analysis before allo-SCT is a poor diagnostic tool for prediction of rejection. | |
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MedLine Citation:
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PMID: 19561647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The predictive value of cytotoxic crossmatch analysis before allo-SCT remains unclear. We retrospectively analyzed the clinical impact of cytotoxic T- and B-cell crossmatch testing before allo-SCT between January 2000 and June 2005. Cytotoxic crossmatches were performed in 157 patients receiving stem cells from matched unrelated donors or an HLA-A, -B or -DRB1 allele mismatched graft. Ninety patients are still alive. Eleven patients rejected their grafts. One of 11 patients with rejection was positive in a T-cell crossmatch before allo-SCT and 4 of 11 in B-cell crossmatches. T-cell crossmatches showed a sensitivity of 9% and a specificity of 97% compared with 36 and 86% for B-cell crossmatches. Positive T- and/or B-crossmatch before SCT had no predictive value for survival in this study as compared with patients with a negative crossmatch. In conclusion, the pretransplant cytotoxic T- and/or B-crossmatch is a poor predictor of rejection after allo-SCT. |
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Authors:
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J Mattsson; A Nordlander; M Remberger; M Uhlin; J Holgersson; O Ringd?n; D Hauzenberger |
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Publication Detail:
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Type: Journal Article Date: 2009-06-29 |
Journal Detail:
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Title: Bone marrow transplantation Volume: 45 ISSN: 1476-5365 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-10 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: England |
Other Details:
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Languages: eng Pagination: 235-8 Citation Subset: IM |
Affiliation:
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Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden. Jonas.Mattsson@ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged B-Lymphocytes / immunology* Child Child, Preschool Female Graft Rejection / immunology* Graft Survival / immunology Histocompatibility Testing* Humans Infant Male Middle Aged Predictive Value of Tests Retrospective Studies Risk Factors Stem Cell Transplantation / methods* T-Lymphocytes / immunology* Transplantation, Homologous / immunology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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