| Cytotoxic coumarins and lignans from extracts of the northern prickly ash (Zanthoxylum americanum). | |
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MedLine Citation:
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PMID: 11507740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four pyranocoumarins; dipetaline, alloxanthoxyletin, xanthoxyletin and xanthyletin; and two lignans; sesamin and asarinin were isolated from the northern prickly ash, Zanthoxylum americanum. To varying degrees, all inhibited the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. Dipetaline was the most active with an IC(50) of 0.68 ppm, followed by alloxanthoxyletin (1.31 ppm), sesamin (2.71 ppm), asarinin (4.12 ppm), xanthoxyletin (3.48 ppm) and xanthylletin (3.84 ppm). |
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Authors:
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Y Ju; C C Still; J N Sacalis; J Li; C T Ho |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 15 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-16 Completed Date: 2001-10-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 441-3 Citation Subset: IM |
Copyright Information:
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Copyright 2001 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Plant Science, Cook College, Rutgers University, New Brunswick, NJ 08903, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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chemistry,
pharmacology*,
therapeutic use Coumarins / chemistry, pharmacology*, therapeutic use HL-60 Cells / drug effects Humans Leukemia / prevention & control* Lignans / chemistry, pharmacology*, therapeutic use Plant Extracts / pharmacology, therapeutic use Plant Stems Plants, Medicinal* Rosales* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Coumarins; 0/Lignans; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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