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Cytotoxic cholestane-type and ergostane-type steroids from the aerial parts of Euphorbia altotibetic.
MedLine Citation:
PMID:  23131765     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Phytochemical investigation of the ethanol extract obtained from the aerial parts of the Euphorbia altotibetic PAULS. grown in China resulted in the isolation of three new cholestane-type and three new ergostane-type steroids (cholest-5-en-2β, 4β-diol; cholest-5-en-1β, 4β-diol; cholest-5-en-1α, 3β, 4 α -triol; (22E)-ergosta-7,9,22-trien- 3β-ol β-D-glucoside; 5α-methoxy-(22E)-ergosta-7,9,22-trien-3β-ol β-D-glucoside; 6β- methoxy-(22E)-ergosta-7,9,22-trien-3β-ol β-D-glucoside), along with seven known compounds. Their structures were established by extensive one- and two-dimensional NMR spectroscopy, as well as other spectrum and chemical analysis. The isolated new steroids exhibited potent anti-tumor activity against the HeLa cell and Hep-G2 cell with the 50% inhibiting concentration values ranging from 1.9 to 9.2 μg/mL.
Authors:
Bei-Bei Zhang; Xue-Lian Han; Qian Jiang; Zhi-Xin Liao; Heng-Shan Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-3
Journal Detail:
Title:  Steroids     Volume:  -     ISSN:  1878-5867     ISO Abbreviation:  Steroids     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China.
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