| Cytotoxic and cancerostatic effect of 1,4-dithiaanthraquinone-2,3-dicarbonitrile. | |
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MedLine Citation:
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PMID: 740057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1,4-Dithiaanthraquinone-2,3-dicarbonitrile (DTA) has been found to exert a considerable cytostatic effect especially on some of the investigated types of eukaryotic cells, concretely on the HeLa cells, moulds, yeasts, protozoa and algae. In cells of the Ehrlich ascites carcinoma (EAC) DTA after a short exposition causes a parallel inhibition of incorporation of 14C-adenine and 14C-valine, in proportion to its rising concentration. The inhibition of biosynthetic processes thus made manifest, is probably a consequence of the primary DTA intervention into the energy metabolism of EAC cells, particularly in glycolysis. The effect of DTA in concentrations capable of bringing about full inhibition of glucose consumption or lactate formation in EAC cells also results in a loss of their transplantability. On the other hand, DTA also exerts a cancerostatic effect on the Ehrlich ascites carcinoma in mice. |
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Authors:
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L Drobnica; E Sturdík; K Horáková; M Miko |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neoplasma Volume: 25 ISSN: 0028-2685 ISO Abbreviation: Neoplasma Publication Date: 1978 |
Date Detail:
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Created Date: 1979-04-28 Completed Date: 1979-04-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0377266 Medline TA: Neoplasma Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 577-84 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algae
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drug effects Animals Anthraquinones / pharmacology* Anti-Bacterial Agents Antifungal Agents Antineoplastic Agents* Carcinoma, Ehrlich Tumor / drug therapy*, metabolism Cell Survival / drug effects Glycolysis / drug effects Hela Cells / drug effects Mice Nitriles / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anthraquinones; 0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Antineoplastic Agents; 0/Nitriles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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