Document Detail


Cytotoxic and cancerostatic effect of 1,4-dithiaanthraquinone-2,3-dicarbonitrile.
MedLine Citation:
PMID:  740057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1,4-Dithiaanthraquinone-2,3-dicarbonitrile (DTA) has been found to exert a considerable cytostatic effect especially on some of the investigated types of eukaryotic cells, concretely on the HeLa cells, moulds, yeasts, protozoa and algae. In cells of the Ehrlich ascites carcinoma (EAC) DTA after a short exposition causes a parallel inhibition of incorporation of 14C-adenine and 14C-valine, in proportion to its rising concentration. The inhibition of biosynthetic processes thus made manifest, is probably a consequence of the primary DTA intervention into the energy metabolism of EAC cells, particularly in glycolysis. The effect of DTA in concentrations capable of bringing about full inhibition of glucose consumption or lactate formation in EAC cells also results in a loss of their transplantability. On the other hand, DTA also exerts a cancerostatic effect on the Ehrlich ascites carcinoma in mice.
Authors:
L Drobnica; E Sturdík; K Horáková; M Miko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  25     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1978  
Date Detail:
Created Date:  1979-04-28     Completed Date:  1979-04-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  577-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Algae / drug effects
Animals
Anthraquinones / pharmacology*
Anti-Bacterial Agents
Antifungal Agents
Antineoplastic Agents*
Carcinoma, Ehrlich Tumor / drug therapy*,  metabolism
Cell Survival / drug effects
Glycolysis / drug effects
Hela Cells / drug effects
Mice
Nitriles / pharmacology
Chemical
Reg. No./Substance:
0/Anthraquinones; 0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Antineoplastic Agents; 0/Nitriles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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