| Cytotoxic benzil and coumestan derivatives from Tephrosia calophylla. | |
| | |
MedLine Citation:
|
PMID: 19062050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A benzil, calophione A, 1-(6'-Hydroxy-1',3'-benzodioxol-5'-yl)-2-(6''-hydroxy-2''-isopropenyl-2'',3''-dihydro-benzofuran-5''-yl)-ethane-1,2-dione and three coumestan derivatives, tephcalostan B, C and D were isolated from the roots of Tephrosia calophylla. Their structures were deduced from spectroscopic data, including 2D NMR (1)H-(1)H COSY and (13)C-(1)H COSY experiments. Compounds were evaluated for cytotoxicity against RAW (mouse macrophage cells) and HT-29 (colon cancer cells) cancer cell lines and antiprotozoal activity against various parasitic protozoa. Calophione A exhibited significant cytotoxicity with IC(50) of 5.00 (RAW) and 2.90microM (HT-29), respectively. |
| | |
Authors:
|
Seru Ganapaty; Guttula Veera Kantha Srilakshmi; Steve Thomas Pannakal; Hafizur Rahman; Hartmut Laatsch; Reto Brun |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-04 |
Journal Detail:
|
Title: Phytochemistry Volume: 70 ISSN: 0031-9422 ISO Abbreviation: Phytochemistry Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2009-02-09 Completed Date: 2009-05-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0151434 Medline TA: Phytochemistry Country: United States |
Other Details:
|
Languages: eng Pagination: 95-9 Citation Subset: IM |
Affiliation:
|
Pharmacognosy and Phytochemistry Division, Department of Pharmaceutical, Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India. ganapatyseru@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antineoplastic Agents, Phytogenic / chemistry*, pharmacology* Benzoates / chemistry*, pharmacology* Cell Line, Tumor Coumarins / chemistry*, pharmacology* Humans Macrophages / drug effects Mice Molecular Structure Plant Roots / chemistry Tephrosia / chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents, Phytogenic; 0/Benzoates; 0/Coumarins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biogeographical distribution and diversity of bacterial and archaeal communities within highly pollu...
Next Document: Xanthone biosynthesis in Hypericum perforatum cells provides antioxidant and antimicrobial protectio...