Document Detail


Cytotoxic benzil and coumestan derivatives from Tephrosia calophylla.
MedLine Citation:
PMID:  19062050     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A benzil, calophione A, 1-(6'-Hydroxy-1',3'-benzodioxol-5'-yl)-2-(6''-hydroxy-2''-isopropenyl-2'',3''-dihydro-benzofuran-5''-yl)-ethane-1,2-dione and three coumestan derivatives, tephcalostan B, C and D were isolated from the roots of Tephrosia calophylla. Their structures were deduced from spectroscopic data, including 2D NMR (1)H-(1)H COSY and (13)C-(1)H COSY experiments. Compounds were evaluated for cytotoxicity against RAW (mouse macrophage cells) and HT-29 (colon cancer cells) cancer cell lines and antiprotozoal activity against various parasitic protozoa. Calophione A exhibited significant cytotoxicity with IC(50) of 5.00 (RAW) and 2.90microM (HT-29), respectively.
Authors:
Seru Ganapaty; Guttula Veera Kantha Srilakshmi; Steve Thomas Pannakal; Hafizur Rahman; Hartmut Laatsch; Reto Brun
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-04
Journal Detail:
Title:  Phytochemistry     Volume:  70     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Affiliation:
Pharmacognosy and Phytochemistry Division, Department of Pharmaceutical, Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India. ganapatyseru@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / chemistry*,  pharmacology*
Benzoates / chemistry*,  pharmacology*
Cell Line, Tumor
Coumarins / chemistry*,  pharmacology*
Humans
Macrophages / drug effects
Mice
Molecular Structure
Plant Roots / chemistry
Tephrosia / chemistry*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Benzoates; 0/Coumarins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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