| Cytotoxic and apoptogenic effect of tea (Camellia sinensis var. assamica) root extract (TRE) and two of its steroidal saponins TS1 and TS2 on human leukemic cell lines K562 and U937 and on cells of CML and ALL patients. | |
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MedLine Citation:
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PMID: 16197994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anticancer activity of di- and tri-terpenes and other polyphenolic compounds present in tea is already reported. We evaluated the cytotoxic and apoptogenic effect of tea root extract (TRE) and two of its steroidal saponins named as TS1 and TS2, on human cell lines and on cells from leukemic patients. It was found that TRE, TS1 and TS2 significantly decreased cell count and that TRE caused apoptosis, as confirmed morphologically by confocal microscopy and by flow-cytometric analysis using Annexin-V FITC and propidium iodide (PI). Cell count and MTT assay in normal white blood cells (WBC) of healthy volunteers revealed that TRE produced insignificant reduction in cell count and cytotoxicity. |
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Authors:
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Papiya Ghosh; Shila E Besra; Gayatri Tripathi; Smita Mitra; Joseph R Vedasiromoni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-28 |
Journal Detail:
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Title: Leukemia research Volume: 30 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-02-21 Completed Date: 2006-04-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 459-68 Citation Subset: IM |
Affiliation:
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Drug Development Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata, 700032 West Bengal, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis DNA Replication / drug effects Flow Cytometry Humans K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology* Microscopy, Confocal Plant Extracts / pharmacology* Plant Roots / chemistry* Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology* Saponins / isolation & purification, pharmacology* Tea / chemistry* U937 Cells |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 0/Saponins; 0/Tea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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