| Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells. | |
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MedLine Citation:
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PMID: 19495562 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The S-methyl-thiosemicarbazones of the 2-hydroxy-R-benzaldehyde (R = H, 3-OH 3-OCH(3) or 4-OCH(3)) reacted with the corresponding aldehydes in the presence of FeCl(3) and NiCl(2). New ONNO chelates of iron(III) and nickel(II) with hydroxy- or methoxy-substituted N(1),N(4)-diarylidene-S-methyl-thiosemicarbazones were characterized by means of elemental analysis, conductivity and magnetic measurements, UV-Vis, IR and (1)H-NMR spectroscopies. Cytotoxic activities of the compounds were determined using K562 chronic myeloid leukemia and ECV304 human endothelial cell lines by MTT assay. It was determined that monochloro N(1)-4-methoxysalicylidene-N(4)-4-methoxysalicylidene-S-methyl-thiosemicarbazidato-iron(III) complex showed selective anti-leukemic effects in K562 cells while has no effect in ECV304 cells in the 0.53 microg/ml (IC(50)) concentrations. Also, some methoxy-substituted nickel(II) chelates exhibit high cytotoxic activity against both of these cell lines in low concentrations. Cytotoxicity data were evaluated depending on cell lines origin and position of the substituents on aromatic rings. |
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Authors:
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Belkis Atasever; Bahri Ulküseven; Tülay Bal-Demirci; Serap Erdem-Kuruca; Zeynep Solakoğlu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-04 |
Journal Detail:
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Title: Investigational new drugs Volume: 28 ISSN: 1573-0646 ISO Abbreviation: Invest New Drugs Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309330 Medline TA: Invest New Drugs Country: United States |
Other Details:
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Languages: eng Pagination: 421-32 Citation Subset: IM |
Affiliation:
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Faculty of Engineering and Natural Sciences, Sabanci University, 34956, Tuzla, Istanbul, Türkiye. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Chelating Agents / chemical synthesis, chemistry, pharmacology* Drug Screening Assays, Antitumor Humans Inhibitory Concentration 50 Iron Chelating Agents / chemical synthesis, chemistry, pharmacology* K562 Cells Nickel / chemistry, pharmacology* Structure-Activity Relationship Thiosemicarbazones / chemical synthesis, chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Iron Chelating Agents; 0/Thiosemicarbazones; 7440-02-0/Nickel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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