| Cytotoxic Triterpenoids from Berberis koreana. | |
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MedLine Citation:
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PMID: 21928166 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A bioassay-guided fractionation and chemical investigation of the trunk of BERBERIS KOREANA led to the isolation and identification of three new triterpenoids, 2 α,3 α,19 α-trihydroxy-urs-12-en-24-formyl-28-oic acid ( 1), 2 α,3 β,21 α-trihydroxy-urs-12-en-28-oic acid ( 2), and 3 β-acetyloxy-1-oxo-olean-12-en-28-oic acid ( 3), along with seven known triterpenoids ( 4- 10). The structures of these new compounds were determined through spectral analysis, including extensive 2D-NMR data. The new compounds 1- 3 showed significant cytotoxicity against the A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cell lines with IC (50) values ranging from 7.17 to 48.73 µM. |
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Authors:
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Ki Hyun Kim; Sang Un Choi; Kang Ro Lee |
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Publication Detail:
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Type: LETTER Date: 2011-9-16 |
Journal Detail:
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Title: Planta medica Volume: - ISSN: 1439-0221 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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