| Cytotoxic T lymphocyte responses to infectious bronchitis virus infection. | |
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MedLine Citation:
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PMID: 9782315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytotoxic T lymphocyte (CTL) activity to infectious bronchitis virus (IBV) was examined at regular intervals between 3 and 30 days post infection (p.i.). The maximal CTL lysis of target cells infected with IBV with 82% was detected at 10 days p.i. The specific CTL activity began to decrease only after viral loads, which peaked at day 8 p.i. in both kidneys and lungs, started to decline. Therefore, the CTL response correlated with elimination of acute infection. IgM antibody did not appear until day 10 and levels peaked at day 12 p.i. whereas IgG antibody titers were detectable only by day 15 p.i., but continued to increase exponentially until day 30 p.i., the last day examined. IBV specific CTL epitope(s) were mapped within the carboxyl terminal 120 amino acids of nucleocapsid protein. In vivo inoculation of this fragment, as cDNA, induced protection against acute infection. The absence of viral neutralizing epitopes on the nucleocapsid protein would suggest that protection with known CTL eptiope(s) can be induced in the absence of neutralizing antibody. |
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Authors:
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S H Seo; E W Collisson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 440 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1998 |
Date Detail:
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Created Date: 1999-01-13 Completed Date: 1999-01-13 Revised Date: 2004-08-05 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 455-60 Citation Subset: IM |
Affiliation:
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Department of Veterinary Pathobiology, Texas A & M University, College Station 77843-4467, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / blood Chick Embryo Coronavirus Infections / immunology* Epitope Mapping Epitopes, T-Lymphocyte / immunology Immunoglobulin G / blood Infectious bronchitis virus / genetics, immunology* Kidney / pathology, virology Lung / pathology, virology Nucleocapsid / immunology Nucleocapsid Proteins* T-Lymphocytes, Cytotoxic / immunology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Epitopes, T-Lymphocyte; 0/Immunoglobulin G; 0/Nucleocapsid Proteins; 0/nucleocapsid protein, Coronavirus |
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