Document Detail


The Cytotoxic Protein Can Induce Autophagocytosis in Addition to Apoptosis in MCF-7 Human Breast Cancer Cells.
MedLine Citation:
PMID:  22523292     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Phagocytic clearance of dying cells is found in many phagocytes. It has been shown that dying cells can be phagocytosed by other phagocytic cells through autophagic or apoptotic cellular death. To date, whether cancer cells have such phagocytic activity has not been studied. In this study, our data shows that RC-RNase can trigger cell death in human breast cancer MCF-7 cells through the apoptotic pathway. Interestingly, when treated with cytotoxic protein, the remaining MCF-7 cells can phagocytose the dying MCF-7 cells via autophagocytic activity, demonstrated directly by real-time image observation and electron microscopy analysis. To sum up, this study demonstrates for the first time that RC-RNase can trigger apoptosis and autophagocytosis in MCF-7 cancer cells.
Authors:
Giou-Teng Yiang; Yung-Luen Yu; Pei-Lun Chou; Hsiu-Feng Tsai; Li-Ann Chen; Yen Hsieh Chen; Kuo-Jung Su; Jaang-Jiun Wang; DA-Tian Bau; Chyou-Wei Wei
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  26     ISSN:  1791-7549     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  -    
Other Details:
Languages:  ENG     Pagination:  403-409     Citation Subset:  -    
Affiliation:
2 Yuh-Der Road, Taichung, 404 Taiwan, R.O.C.; Tel: +886 422052121 ext. 1523, datian@mail.cmuh.org.tw.
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