Document Detail


Cytotoxic and genotoxic effects of the quercetin/lanthanum complex on human cervical carcinoma cells in vitro.
MedLine Citation:
PMID:  21971105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quercetin is the main flavonoid in diet with a potential in the treatment of cancer, cardiovascular, and neurodegenerative diseases. Due to its specific planar chemical structure, quercetin readily forms chelates with metal ions. Complexes of bioactive compounds and metal ions such as lanthanum often show strong cytotoxic and antitumour properties. The aim of this study was to compare the genotoxic effects of the quercetin/lanthanum complex on human cervical carcinoma cells with compare it to the effects of free ligands, quercetin, and lanthanum alone. The quercetin/lanthanum complex showed considerable cytotoxicity in the concentration range of (100 to 1000) mmol mL-1 and exposure time of three hours. The complex also induced a dose-dependent pro-oxidative effects and the formation of single-strand and double-strand DNA breaks. Although we obtained promising results on the cell level, future experiments should answer whether the quercetin/lanthanum complex is cancer-specific and stable enough in physiological conditions to make a potential new antitumour drug.
Authors:
Ksenija Durgo; Ivana Halec; Ivana Sola; Jasna Franekić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arhiv za higijenu rada i toksikologiju     Volume:  62     ISSN:  0004-1254     ISO Abbreviation:  Arh Hig Rada Toksikol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-05     Completed Date:  2012-01-31     Revised Date:  2012-05-03    
Medline Journal Info:
Nlm Unique ID:  0373100     Medline TA:  Arh Hig Rada Toksikol     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  221-7     Citation Subset:  IM    
Affiliation:
Food Technology and Biotechnology, Zagreb, Croatia. kdurgo@pbf.hr
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MeSH Terms
Descriptor/Qualifier:
Antioxidants
Cell Survival / drug effects
Comet Assay
DNA Breaks / drug effects*
Dose-Response Relationship, Drug
Female
Humans
Lanthanum / pharmacology*
Lipid Peroxidation / drug effects
Quercetin / pharmacology
Tumor Cells, Cultured / drug effects*
Uterine Cervical Neoplasms / genetics,  metabolism,  pathology*
Chemical
Reg. No./Substance:
0/Antioxidants; 117-39-5/Quercetin; 7439-91-0/Lanthanum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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