Document Detail


Cytotoxic activities of several geranyl-substituted flavanones.
MedLine Citation:
PMID:  20192247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nine geranylated flavanones isolated from the fruits of Paulownia tomentosa (4-12) and two from the roots of Morus alba (13 and 14) were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin (1), naringenin (2), and hesperetin (3) and with the standard anticancer drugs olomoucine II, diaziquone, and oxaliplatin and the antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effects of structural changes on cytotoxic activity, including geranyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed.
Authors:
Karel Smejkal; Jana Svacinov?; Tereza Slapetov?; Krist?na Schneiderov?; Stefano Dall'acqua; Gabbriella Innocenti; Veronika Z?valov?; Peter Koll?r; Stanislav Chud?k; Radek Marek; Ondrej Jul?nek; Marie Urbanov?; Murat Kartal; Marek Cs?llei; Karel Dolezal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  73     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  568-72     Citation Subset:  IM    
Affiliation:
Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Palackeho 1-3, CZ-612 42, Czech Republic. karel.mejkal@post.cz
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MeSH Terms
Descriptor/Qualifier:
Angiosperms / chemistry*
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology*
Apoptosis / drug effects
Drug Screening Assays, Antitumor
Fibroblasts / drug effects
Flavanones / chemistry,  isolation & purification*,  pharmacology*
Fruit / chemistry
Humans
Molecular Structure
Morus / chemistry
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Structure-Activity Relationship
Turkey
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Flavanones; 480-41-1/naringenin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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