| Cytotoxic activities of several geranyl-substituted flavanones. | |
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MedLine Citation:
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PMID: 20192247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine geranylated flavanones isolated from the fruits of Paulownia tomentosa (4-12) and two from the roots of Morus alba (13 and 14) were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin (1), naringenin (2), and hesperetin (3) and with the standard anticancer drugs olomoucine II, diaziquone, and oxaliplatin and the antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effects of structural changes on cytotoxic activity, including geranyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed. |
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Authors:
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Karel Smejkal; Jana Svacinov?; Tereza Slapetov?; Krist?na Schneiderov?; Stefano Dall'acqua; Gabbriella Innocenti; Veronika Z?valov?; Peter Koll?r; Stanislav Chud?k; Radek Marek; Ondrej Jul?nek; Marie Urbanov?; Murat Kartal; Marek Cs?llei; Karel Dolezal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of natural products Volume: 73 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 568-72 Citation Subset: IM |
Affiliation:
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Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Palackeho 1-3, CZ-612 42, Czech Republic. karel.mejkal@post.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiosperms
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chemistry* Antineoplastic Agents, Phytogenic / chemistry, isolation & purification*, pharmacology* Apoptosis / drug effects Drug Screening Assays, Antitumor Fibroblasts / drug effects Flavanones / chemistry, isolation & purification*, pharmacology* Fruit / chemistry Humans Molecular Structure Morus / chemistry Nuclear Magnetic Resonance, Biomolecular Plant Roots / chemistry Plants, Medicinal / chemistry* Structure-Activity Relationship Turkey |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Flavanones; 480-41-1/naringenin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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