Document Detail


Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi.
MedLine Citation:
PMID:  17323647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 microg/ml, respectively.
Authors:
Nahyun Kim; Jin Chul Shin; Woncheol Kim; Bang Yeon Hwang; Beom Seok Kim; Young-Soo Hong; Dongho Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  59     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-27     Completed Date:  2007-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  797-800     Citation Subset:  IM    
Affiliation:
Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemistry,  isolation & purification*,  pharmacology
Cell Line, Tumor
Humans
Salicylates / chemistry,  isolation & purification*,  pharmacology
Salicylic Acids / chemistry,  isolation & purification*,  pharmacology
Streptomyces / metabolism*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Salicylates; 0/Salicylic Acids; 0/salaceyin A; 0/salaceyin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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