Document Detail

Cytosystems dynamics in self-organization of tissue architecture.
MedLine Citation:
PMID:  23325214     Owner:  NLM     Status:  In-Process    
Our knowledge of the principles by which organ architecture develops through complex collective cell behaviours is still limited. Recent work has shown that the shape of such complex tissues as the optic cup forms by self-organization in vitro from a homogeneous population of stem cells. Multicellular self-organization involves three basic processes that are crucial for the emergence of latent intrinsic order. Based on lessons from recent studies, cytosystems dynamics is proposed as a strategy for understanding collective multicellular behaviours, incorporating four-dimensional measurement, theoretical modelling and experimental reconstitution.
Yoshiki Sasai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  493     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  318-26     Citation Subset:  IM    
Neurogenesis and Organogenesis Group, RIKEN Center for Development Biology, Kobe 650-0047, Japan.
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