Document Detail

Cytostatics and anastomotic healing in the intestine: an experimental study on the effect of parenteral nutrition.
MedLine Citation:
PMID:  1582427     Owner:  NLM     Status:  MEDLINE    
The effects of parenteral nutrition on the healing of experimental ileal and colonic anastomoses constructed on the 3rd day of a 5-day cytostatics course were investigated. Intravenous saline alone already reduced weight loss induced by cytostatics while parenteral nutrition almost completely prevented postoperative loss of weight. A negative effect of cytostatics on anastomotic bursting strength was found in the ileum 7 days after operation. Parenteral feeding negated this effect but had no positive effect on anastomotic hydroxyproline content. Thus, parenteral nutrition increases the strength of intestinal anastomoses, constructed during a cytostatics regimen, but intravenous saline alone also appears to have a similar effect.
D B de Roy van Zuidewijn; T Hendriks; T Wobbes; B de Man; H H de Boer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  24     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-12     Completed Date:  1992-06-12     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  103-11     Citation Subset:  IM    
Department of General Surgery, St. Radboud University Hospital, Nijmegen, The Netherlands.
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MeSH Terms
Anastomosis, Surgical
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Body Weight / drug effects
Colon / metabolism,  surgery*
Hydroxyproline / analysis
Ileum / metabolism,  surgery*
Parenteral Nutrition*
Rats, Inbred Strains
Wound Healing* / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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