| Cytostatics and anastomotic healing in the intestine: an experimental study on the effect of parenteral nutrition. | |
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MedLine Citation:
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PMID: 1582427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of parenteral nutrition on the healing of experimental ileal and colonic anastomoses constructed on the 3rd day of a 5-day cytostatics course were investigated. Intravenous saline alone already reduced weight loss induced by cytostatics while parenteral nutrition almost completely prevented postoperative loss of weight. A negative effect of cytostatics on anastomotic bursting strength was found in the ileum 7 days after operation. Parenteral feeding negated this effect but had no positive effect on anastomotic hydroxyproline content. Thus, parenteral nutrition increases the strength of intestinal anastomoses, constructed during a cytostatics regimen, but intravenous saline alone also appears to have a similar effect. |
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Authors:
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D B de Roy van Zuidewijn; T Hendriks; T Wobbes; B de Man; H H de Boer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 24 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1992 |
Date Detail:
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Created Date: 1992-06-12 Completed Date: 1992-06-12 Revised Date: 2006-11-30 |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 103-11 Citation Subset: IM |
Affiliation:
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Department of General Surgery, St. Radboud University Hospital, Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical Animals Antineoplastic Combined Chemotherapy Protocols / adverse effects* Body Weight / drug effects Colon / metabolism, surgery* Hydroxyproline / analysis Ileum / metabolism, surgery* Male Parenteral Nutrition* Rats Rats, Inbred Strains Wound Healing* / drug effects |
| Chemical | |
Reg. No./Substance:
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51-35-4/Hydroxyproline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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