| Cytosolic sulfotransferases. | |
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MedLine Citation:
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PMID: 16538854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sulfoconjugation (Sulfation or Sulfonation) is an important reaction in the phase II biotransformation of a wide number of endogenous and foreign chemicals, including: drugs, toxic chemicals, hormones, and neurotransmitters. The reaction is catalyzed by the members of the cytosolic sulfotransferase (SULT) superfamily, consisting of ten functional genes in humans. Sulfation reaction in living cells is reversed by sulfatase, which hydrolyses the sulfonated conjugates. It has a major role in regulating the endocrine status of an individual by modulating the activity of steroid hormones, their biosynthesis, and the metabolism of catecholamines. Sulfonation is a key reaction in the body's 'chemical' defense against xenobiotics. Although the primary function of sulfoconjugation is to permit detoxification of the compound, it also results in the activation of chemical procarcinogens, such as certain dietary and environmental agents into carcinogens. In this review, we summarize our current understanding of the structure of mammalian cytosolic sulfotransferases and their role in human steroid associated cancers and in the bioactivation of chemical carcinogens. |
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Authors:
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Deepthi Nimmagadda; Ganesh Cherala; Srinivas Ghatta |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 44 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-16 Completed Date: 2006-08-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: India |
Other Details:
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Languages: eng Pagination: 171-82 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, ND 581035, USA. Deepthi.Nimmagadda@ndsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytosol / enzymology* Humans Neoplasms / enzymology Steroids / metabolism Substrate Specificity Sulfotransferases / chemistry, metabolism* Terminology as Topic |
| Chemical | |
Reg. No./Substance:
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0/Steroids; EC 2.8.2.-/Sulfotransferases |
| Comments/Corrections | |
Erratum In:
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Indian J Exp Biol. 2006 May;44(5):348 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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