Document Detail


Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.
MedLine Citation:
PMID:  8162848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic data from Drosophila have suggested a functional relationship between the novel cytoplasmic protein encoded by the deltex locus and the transmembrane receptor encoded by Notch. We have demonstrated a direct interaction between these proteins from expression studies conducted in cultured cells, in yeast, and in the imaginal wing disc. deltex binds specifically to the Notch ankyrin repeats, a region that is crucial for Notch signaling and that constitutes the most conserved domain among Notch family members. In addition, we present a new Notch allele, Nsu42c, that is associated with a missense mutation within the fifth ankyrin repeat. In addition to representing a new class of viable Notch allele, this mutation behaves similarly to mutations of deltex and further implicates the ankyrin repeats in Notch function.
Authors:
R J Diederich; K Matsuno; H Hing; S Artavanis-Tsakonas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  120     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-05-20     Completed Date:  1994-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  473-81     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536-0812.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Animals
Ankyrin Repeat / physiology*
Base Sequence
Cells, Cultured
Drosophila / embryology,  genetics*
Drosophila Proteins
Insect Hormones / genetics,  physiology*
Membrane Proteins / genetics,  physiology
Molecular Sequence Data
Receptors, Notch
Saccharomyces cerevisiae / genetics
Signal Transduction / genetics*
Wing / embryology
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Insect Hormones; 0/Membrane Proteins; 0/Receptors, Notch; 0/notch protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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