Document Detail


Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands.
MedLine Citation:
PMID:  12479566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytosolic long-chain fatty acid binding proteins (FABPs) are found in tissues that metabolize fatty acids. Like most lipid binding proteins, their specific functions remain unclear. Two classes have been described. Membrane-active FABPs interact directly with membranes during exchange of fatty acids between the protein binding site and the membrane, while membrane-inactive FABPs bind only to fatty acids that are already in aqueous solution. Despite these binding proteins, most fatty acids in cell cytoplasm appear to be bound to membranes. This paper reviews data suggesting that FABPs catalyze transfer of fatty acids between intracellular membranes, often across considerable intracellular distances. This process occurs in three distinct steps: dissociation of the fatty acid from a 'donor' membrane, diffusion of the fatty acid across the intervening water layer, and binding to an 'acceptor' membrane. Membrane-active FABPs catalyze dissociation of the fatty acid from the donor membrane and binding to the acceptor membrane, while membrane-inactive FABPs catalyze diffusion of fatty acids across the aqueous cytosol. Thus, FABPs catalyze all three steps in intracellular transport. A simple quantitative model has been developed that predicts the rate of intracellular transport as a function of the concentration, affinity and diffusional mobility of the binding protein. Different FABPs may have evolved to match the specific transport requirements of the cell type within which they are found.
Authors:
Richard A Weisiger
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  239     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-12-13     Completed Date:  2003-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  35-43     Citation Subset:  IM    
Affiliation:
Department of Medicine and the Liver Center, University of California, San Francisco, CA 94143-0538, USA. dickw@itsa.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Carrier Proteins / metabolism*
Cell Membrane / metabolism
Cytoplasm / metabolism*
Fatty Acid-Binding Proteins
Fatty Acids / metabolism*
Humans
Ligands
Neoplasm Proteins*
Thermodynamics
Tumor Suppressor Proteins*
Grant Support
ID/Acronym/Agency:
DK 26743/DK/NIDDK NIH HHS; DK 32898/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/FABP7 protein, human; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids; 0/Ligands; 0/Neoplasm Proteins; 0/Tumor Suppressor Proteins

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