Document Detail

Cytosolic Ca2+ and the regulation of secretion in parathyroid cells.
MedLine Citation:
PMID:  3755106     Owner:  NLM     Status:  MEDLINE    
The concentration of intracellular Ca2+ [( Ca2+]i) was measured in dissociated bovine parathyroid cells loaded with quin-2 or fura-2. In quin-2-loaded cells, increases in the concentration of extracellular Ca2+ elicited slow, monophasic increases in [Ca2+]i, whereas in fura-2-loaded cells, extracellular Ca2+ evoked rapid, transient increases which were followed by lower, yet sustained increases in [Ca2+]i. Cytosolic Ca2+ transients arose from the mobilization of cellular Ca2+ and could be evoked by a variety of divalent cations. Transient, but not sustained increases in [Ca2+]i were associated with an inhibition of hormone secretion. Secretion was still inhibited, however, when cytosolic Ca2+ transients were blocked by buffering with quin-2, suggesting that changes in [Ca2+]i might not be the essential factor regulating secretion in parathyroid cells.
E F Nemeth; A Scarpa
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  FEBS letters     Volume:  203     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-08-21     Completed Date:  1986-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
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MeSH Terms
Aminoquinolines / diagnostic use
Benzofurans / diagnostic use
Calcium / physiology*
Cytosol / physiology
Lanthanum / pharmacology
Magnesium / pharmacology
Parathyroid Glands / secretion*
Secretory Rate / drug effects
Grant Support
Reg. No./Substance:
0/Aminoquinolines; 0/Benzofurans; 7439-91-0/Lanthanum; 7439-95-4/Magnesium; 7440-70-2/Calcium; 83104-85-2/Quin2-acetoxymethyl ester; 96314-98-6/Fura-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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