| Cytoskeletal networks and the regulation of cardiac contractility: microtubules, hypertrophy, and cardiac dysfunction. | |
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MedLine Citation:
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PMID: 16679401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cytoskeleton as classically defined for eukaryotic cells consists of three systems of protein filaments: the microtubules, the intermediate filaments, and the microfilaments. In mature striated muscle such as the heart of the adult mammal, these three types of cytoskeletal filaments are superimposed spatially on the myofilaments, a specialized system of contractile protein filaments. Each of these systems of protein filaments has the potential to respond in an adaptive or maladaptive manner during load-induced hypertrophic cardiac growth. However, the extent to which such hypertrophy is compensatory is also critically dependent on the type of hemodynamic overload that serves as the hypertrophic stimulus. Thus cardiac hypertrophy is not intrinsically maladaptive; rather, it is the nature of the inducing load rather than hypertrophy itself that is responsible, through effects on structural and/or regulatory proteins, for the frequent deterioration of initially compensatory hypertrophy into the congestive heart failure state. As one example reviewed here of this load specificity of maladaptation, increased microtubule network density is a persistent feature of severely pressure-overloaded, hypertrophied, and failing myocardium that imposes a primarily viscous load on active myofilaments during contraction. |
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Authors:
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George Cooper |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2006-05-05 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 291 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-10 Completed Date: 2006-09-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1003-14 Citation Subset: IM |
Affiliation:
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Gazes Cardiac Research Institute, Cardiology Division, PO Box 250773, Medical University of South Carolina, and Department of Veterans Affairs Medical Center, Charleston, SC 29403, USA. cooperge@musc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics Cytoskeleton / physiology*, ultrastructure Heart / physiopathology* Heart Diseases / physiopathology Humans Hypertrophy Microfilaments / physiology, ultrastructure Microtubules / physiology*, ultrastructure Myocardial Contraction / physiology* Myocardium / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-48788/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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