Document Detail

Cytoskeletal identification of intermediate filaments in the inner ear of the jerker mouse mutant.
MedLine Citation:
PMID:  2648748     Owner:  NLM     Status:  MEDLINE    
The expression of the five main groups of intermediate filaments (IF) and their subgroups, especially cytokeratins, was analysed in cryosections of the labyrinth of the jerker mouse mutant and compared with normal CBA/CBA controls. Fourteen different well characterized monoclonal antibodies were used. In principle the same pattern of IF was found in the two mouse strains. IF were not found in hair cells of the mouse inner ear, which may reflect a disparity as compared with human fetal hair cells. Chain-specific (epitope-specific) differences were visualized in cytokeratin no. 8 with regard to cells in epithelia involved in the homeostasis of inner ear fluids. Differences in immuno-staining occurred between adjacent cells in the same epithelium, for instance in the semicircular canals.
M Anniko; B Sjöström; L E Thornell; I Virtanen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  107     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:    1989 Mar-Apr
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  191-201     Citation Subset:  IM    
Department of Oto-Rhino-Laryngology and Head & Neck Surgery, University Hospital, Umeå, Sweden.
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MeSH Terms
Antibodies, Monoclonal / diagnostic use
Cytoskeleton / ultrastructure*
Ear, Inner / ultrastructure*
Hair Cells, Auditory / analysis
Immunoenzyme Techniques
Intermediate Filament Proteins / analysis*
Intermediate Filaments / ultrastructure*
Mice, Inbred CBA
Mice, Neurologic Mutants / anatomy & histology*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Intermediate Filament Proteins

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