| Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism. | |
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MedLine Citation:
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PMID: 10622279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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T cell apoptosis can be triggered by different mechanisms that lead to distinctive features such as cell shrinkage, membrane blebbing, phosphatidylserine externalization, and internucleosomal DNA fragmentation. Prevailing models for the induction of apoptosis place the cytoskeleton as a distal target of the death effector molecules ('executioners'). However, the cytoskeleton can also play a role in the induction of apoptosis as suggested by the finding that cytoskeletal disruption can induce apoptosis. The mechanism by which this occurs is unknown. Here, we report that T cell apoptosis by cytoskeletal disruption involves a protein synthesis-independent mechanism leading to up-regulation of caspase-3 protease activity and increased accessibility of active caspase-3 to its substrate. Thus, cytoskeleton integrity may regulate the subcellular compartmentalization of death effector molecules. |
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Authors:
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H Suria; L A Chau; E Negrou; D J Kelvin; J Madrenas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 65 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1999 |
Date Detail:
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Created Date: 2000-01-20 Completed Date: 2000-01-20 Revised Date: 2010-01-20 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2697-707 Citation Subset: IM |
Affiliation:
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Transplantation and Immunobiology Group, The John P. Robarts Research Institute, London, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Annexin A5 / analysis Apoptosis* Caspase 3 Caspases / metabolism* Cell Line Cytochalasin B / pharmacology Cytochalasin D / pharmacology Cytochalasins / pharmacology Cytoskeleton / drug effects, physiology* DNA Fragmentation Mice Nucleic Acid Synthesis Inhibitors / pharmacology T-Lymphocytes / cytology* |
| Chemical | |
Reg. No./Substance:
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0/Annexin A5; 0/Cytochalasins; 0/Nucleic Acid Synthesis Inhibitors; 14110-64-6/cytochalasin A; 14930-96-2/Cytochalasin B; 22144-77-0/Cytochalasin D; EC 3.4.22.-/Casp3 protein, mouse; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases |
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