Document Detail


Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism.
MedLine Citation:
PMID:  10622279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T cell apoptosis can be triggered by different mechanisms that lead to distinctive features such as cell shrinkage, membrane blebbing, phosphatidylserine externalization, and internucleosomal DNA fragmentation. Prevailing models for the induction of apoptosis place the cytoskeleton as a distal target of the death effector molecules ('executioners'). However, the cytoskeleton can also play a role in the induction of apoptosis as suggested by the finding that cytoskeletal disruption can induce apoptosis. The mechanism by which this occurs is unknown. Here, we report that T cell apoptosis by cytoskeletal disruption involves a protein synthesis-independent mechanism leading to up-regulation of caspase-3 protease activity and increased accessibility of active caspase-3 to its substrate. Thus, cytoskeleton integrity may regulate the subcellular compartmentalization of death effector molecules.
Authors:
H Suria; L A Chau; E Negrou; D J Kelvin; J Madrenas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  65     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1999  
Date Detail:
Created Date:  2000-01-20     Completed Date:  2000-01-20     Revised Date:  2010-01-20    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2697-707     Citation Subset:  IM    
Affiliation:
Transplantation and Immunobiology Group, The John P. Robarts Research Institute, London, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Annexin A5 / analysis
Apoptosis*
Caspase 3
Caspases / metabolism*
Cell Line
Cytochalasin B / pharmacology
Cytochalasin D / pharmacology
Cytochalasins / pharmacology
Cytoskeleton / drug effects,  physiology*
DNA Fragmentation
Mice
Nucleic Acid Synthesis Inhibitors / pharmacology
T-Lymphocytes / cytology*
Chemical
Reg. No./Substance:
0/Annexin A5; 0/Cytochalasins; 0/Nucleic Acid Synthesis Inhibitors; 14110-64-6/cytochalasin A; 14930-96-2/Cytochalasin B; 22144-77-0/Cytochalasin D; EC 3.4.22.-/Casp3 protein, mouse; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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