Document Detail

Cytosine arabinoside induced liver damage: histopathologic demonstration.
MedLine Citation:
PMID:  6577264     Owner:  NLM     Status:  MEDLINE    
Two patients with acute leukemia developed abnormal liver function tests after the administration of cytosine arabinoside. Other possible causes for such abnormalities were not likely. In both patients a close chronologic relationship between the administration of the drug and the appearance of the laboratory abnormalities was noted. The liver damage was also documented by biopsy. To our knowledge this is the first time that the hepatotoxic effects of cytosine arabinoside are histologically demonstrated.
J Pizzuto; A Avilés; E Ramos; J Cervera; J Aguirre
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medical and pediatric oncology     Volume:  11     ISSN:  0098-1532     ISO Abbreviation:  Med. Pediatr. Oncol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7506654     Medline TA:  Med Pediatr Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-90     Citation Subset:  IM    
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MeSH Terms
Cytarabine / adverse effects*
Leukemia, Myeloid, Acute / drug therapy*
Liver / drug effects*,  pathology
Middle Aged
Reg. No./Substance:

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