| Cytoreductive surgery in multidisciplinary treatment of advanced hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 18522575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cytoreductive surgery (debulking surgery) as a multidisciplinary treatment approach for inoperable advanced hepatocellular carcinoma has been shown to prolong survival and provide symptomatic relief for good surgical risks patients in non-randomized studies before. METHODS: A non-randomized comparative study was performed in a tertiary referral centre between January 2001 and December 2006. The outcome of a consecutive series of patients with inoperable advanced hepatocellular carcinoma who received cytoreductive surgery was compared with a control group of patients who received palliative treatment without surgery. Two techniques of cytoreductive surgery were used: (i) partial hepatectomy for the main tumour plus intraoperative local ablative therapy for the smaller tumour nodules in the liver remnant; and (ii) partial hepatectomy for the main tumour plus postoperative transarterial chemoembolization. RESULTS: The overall survival of cytoreductive surgery group (n = 18) was significantly better than that of the palliative treatment group (n = 15) (3-year overall survival, 54% vs 22%; median survival, 18 vs 11 months) (P =0.038). In the cytoreductive surgery group, there was no operative mortality. Postoperative morbidity rate was 16.7%. The mean hospital stay was 8 days. CONCLUSION: Cytoreductive treatment strategy for advanced hepatocellular carcinoma can be considered as one of the options in selected patients with low operative risks and reasonable liver function. Further prospective randomized trials are required to validate this aggressive surgical approach. |
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Authors:
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Eric C H Lai; Chung-Ngai Tang; Joe P Y Ha; David K K Tsui; Michael K W Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: ANZ journal of surgery Volume: 78 ISSN: 1445-2197 ISO Abbreviation: ANZ J Surg Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-04 Completed Date: 2008-06-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101086634 Medline TA: ANZ J Surg Country: Australia |
Other Details:
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Languages: eng Pagination: 504-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, China. ericlai@alumni.cuhk.edu.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Hepatocellular / mortality, pathology, surgery* Catheter Ablation Chemoembolization, Therapeutic Female Hepatectomy / mortality* Humans Liver Neoplasms / mortality, pathology, surgery* Male Middle Aged Neoplasm Staging Retrospective Studies Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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