| Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells. | |
| | |
MedLine Citation:
|
PMID: 18481334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the process of glycation, methylglyoxal is a reactive dicarbonyl compound physiologically generated as an intermediate of glycolysis, and is found in high levels in blood or tissue of diabetic models. Biological glycation has been commonly implicated in the development of diabetic microvascular complications of neuropathy. Increasing evidence suggests that neuronal cell cycle regulatory failure followed by apoptosis is an important mechanism in the development of diabetic neuropathy complication. Naturally occurring antioxidants, especially phenolic acids have been recommended as the major bioactive compounds to prevent chronic diseases and promote health benefits. The objective of this study was to investigate the inhibitory abilities of phenolic acids (chlorogenic acid, syringic acid and vanillic acid) on methylglyoxal-induced mouse Neuro-2A neuroblastoma (Neuro-2A) cell apoptosis in the progression of diabetic neuropathy. The data indicated that methylglyoxal induced mouse Neuro-2A neuroblastoma (Neuro-2A) cell apoptosis via alternation of mitochondria membrane potential and Bax/Bcl-2 ratio, activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase. Furthermore, the results demonstrated that activation of mitogen-activated protein kinase signal pathways (JNK and p38) participated in the methylglyoxal-induced Neuro-2A cell apoptosis process. Treatment of Neuro-2A cells with phenolic acids markedly suppresses cell apoptosis induced by methylglyoxal, suggesting that phenolic acids possess cytoprotective ability in the prevention of diabetic neuropathy complication. |
| | |
Authors:
|
Shang-Ming Huang; Hong-Chih Chuang; Chi-Hao Wu; Gow-Chin Yen |
Related Documents
:
|
17442474 - Norcantharidin preferentially induces apoptosis in human leukemic jurkat cells without ... 12934064 - Apoptosis caused by cathepsins does not require bid signaling in an in vivo model of pr... 9930654 - Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nu... 19254774 - Induction of apoptosis by hax-1 sirna in melanoma cells. 22479404 - Lilra2 selectively modulates lps-mediated cytokine production and inhibits phagocytosis... 18569454 - Molecular mechanism(s) involved in the synergistic induction of cxcl10 by human immunod... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Molecular nutrition & food research Volume: 52 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-08-26 Completed Date: 2008-10-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 940-9 Citation Subset: IM |
Affiliation:
|
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis / drug effects* Caspase 3 / metabolism Cell Line, Tumor Cell Survival / drug effects Chlorogenic Acid / pharmacology Cytoprotection* Diabetic Neuropathies / prevention & control* Gallic Acid / analogs & derivatives, pharmacology Hydroxybenzoic Acids / pharmacology* L-Lactate Dehydrogenase / secretion MAP Kinase Signaling System Membrane Potential, Mitochondrial / drug effects Mice Neuroblastoma / pathology* Poly(ADP-ribose) Polymerases / metabolism Proto-Oncogene Proteins c-bcl-2 / analysis Pyruvaldehyde / toxicity* Vanillic Acid / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Hydroxybenzoic Acids; 0/Proto-Oncogene Proteins c-bcl-2; 121-34-6/Vanillic Acid; 149-91-7/Gallic Acid; 29656-58-4/phenolic acid; 327-97-9/Chlorogenic Acid; 530-57-4/syringic acid; 78-98-8/Pyruvaldehyde; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 3.4.22.-/Caspase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selenium attenuates pro-inflammatory gene expression in macrophages.
Next Document: The prescribing of Chinese herbal products in Taiwan: a cross-sectional analysis of the national hea...