Document Detail


Cytoprotective effects of hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonists are mediated by intracellular sulfane sulfur.
MedLine Citation:
PMID:  25431645     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hydrogen sulfide (H2S) exerts a host of biological effects ranging from cytotoxicity to cytoprotection. Cytotoxicity of H2S in neurodegenerative diseases may be mediated by N-methyl-D-aspartate receptor (NMDAR) activation. To exploit cytoprotective effects of H2S while minimizing its toxicity, we synthesized a series of H2S-releasing NMDAR antagonists and examined their effects against 1-methyl-4-phenylpyridinium (MPP(+))-induced cell death, a cellular model of Parkinson's disease. We observed that cytoprotective effect of H2S-releasing NMDAR antagonists correlated with their ability to increase intracellular sulfane sulfur, but not H2S, levels. These studies suggest that H2S-donor compounds that increase intracellular sulfane sulfur are potentially useful neuroprotective agents against neurodegenerative diseases.
Authors:
Eizo Marutani; Masahiro Sakaguchi; Wei Chen; Kiyoshi Sasakura; Jifeng Liu; Ming Xian; Kenjiro Hanaoka; Tetsuo Nagano; Fumito Ichinose
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  MedChemComm     Volume:  5     ISSN:  2040-2503     ISO Abbreviation:  Medchemcomm     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-11-28     Completed Date:  -     Revised Date:  2014-11-29    
Medline Journal Info:
Nlm Unique ID:  101531525     Medline TA:  Medchemcomm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1577-1583     Citation Subset:  -    
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