Document Detail

Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials.
MedLine Citation:
PMID:  23334460     Owner:  NLM     Status:  MEDLINE    
To date, graphene oxide (GO), an oxidized version of graphene, has been utilized in many research areas including bioapplications such as drug delivery and bioanalysis. Unlike other spherical or polygonal nanomaterials, GO exhibits a sheet-like structure, which in itself suggests interesting applications based on its shape. Here we show that GO can protect cells from internalization of toxic hydrophobic molecules, nanoparticles, and nucleic acids such as siRNA and plasmid DNA by interacting with cell surface lipid bilayers without noticeably reducing cell viability. Furthermore, the cytoprotective effect of GO against the internalization of extracellular materials enabled spatial control over gene transfection through region-selective gene delivery only into GO-untreated cells, and not into the GO-treated cells.
Hee-Kyung Na; Mi-Hee Kim; Jieon Lee; Young-Kwan Kim; Hongje Jang; Kyung Eun Lee; Hyerim Park; Won Do Heo; Hyesung Jeon; Insung S Choi; Younghoon Lee; Dal-Hee Min
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nanoscale     Volume:  5     ISSN:  2040-3372     ISO Abbreviation:  Nanoscale     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-16     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  101525249     Medline TA:  Nanoscale     Country:  England    
Other Details:
Languages:  eng     Pagination:  1669-77     Citation Subset:  IM    
Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
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MeSH Terms
Cytoprotection / drug effects*,  physiology*
Endocytosis / drug effects*
Graphite / pharmacology*
HeLa Cells
Materials Testing
Nanostructures / administration & dosage*
Oxides / pharmacology*
Reg. No./Substance:
0/Oxides; 7782-42-5/Graphite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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