Document Detail


Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining.
MedLine Citation:
PMID:  12500159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the cytoprotective effect of melatonin or recombinant human growth hormone (hGH) on the early phase of a running myocardial infarction in rats by using the Feulgen staining. METHODS: Rats were subjected to surgical ligature of the left coronary artery or its sham-operation and were studied 1.5 3 h later. Melatonin was administered in the drinking water (100 microg/ml water) for 7 days before surgery. Recombinant hGH (2 IU/kg) was given ip at the time of surgery. Feulgen-stained histological cardiac sections were examined by light microscopy and image analysis. RESULTS: Infarcted rats receiving vehicle exhibited large, diffuse cardiac lesions with a marked positivity for Feulgen reaction. About 18 20% of the total area recorded became injured 1.5 or 3 h after infarction, respectively. Infarcted rats treated with melatonin or hGH, or the combination of both, and killed 3 h after surgery, showed cardiac sections with scattered lesions and only a few isolated injured muscle fibers. A similar effectiveness of melatonin and hGH, alone or in combination, to decrease injured area by 86 87% and the number of cardiac lesions by 75 80% was observed. CONCLUSION: A significant cytoprotective effect of melatonin or hGH is demonstrable in an early phase of myocardial infarction in rats.
Authors:
Hugo E Castagnino; Néstor Lago; José M Centrella; Silvana D Calligaris; Silvia Fariña; María I Sarchi; Daniel P Cardinali
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  23     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:    2002 Oct-Dec
Date Detail:
Created Date:  2002-12-24     Completed Date:  2003-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  391-5     Citation Subset:  IM    
Affiliation:
Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coloring Agents
Cytoprotection / drug effects*
DNA / analysis
Disease Models, Animal
Drug Evaluation, Preclinical
Drug Therapy, Combination
Growth Hormone / therapeutic use*
Heart / drug effects*
Male
Melatonin / therapeutic use*
Myocardial Infarction / pathology,  prevention & control*
Myocardium / pathology
Rats
Rats, Wistar
Rosaniline Dyes*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Coloring Agents; 0/Feulgen stain; 0/Rosaniline Dyes; 73-31-4/Melatonin; 9002-72-6/Growth Hormone; 9007-49-2/DNA

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