| Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining. | |
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MedLine Citation:
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PMID: 12500159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the cytoprotective effect of melatonin or recombinant human growth hormone (hGH) on the early phase of a running myocardial infarction in rats by using the Feulgen staining. METHODS: Rats were subjected to surgical ligature of the left coronary artery or its sham-operation and were studied 1.5 3 h later. Melatonin was administered in the drinking water (100 microg/ml water) for 7 days before surgery. Recombinant hGH (2 IU/kg) was given ip at the time of surgery. Feulgen-stained histological cardiac sections were examined by light microscopy and image analysis. RESULTS: Infarcted rats receiving vehicle exhibited large, diffuse cardiac lesions with a marked positivity for Feulgen reaction. About 18 20% of the total area recorded became injured 1.5 or 3 h after infarction, respectively. Infarcted rats treated with melatonin or hGH, or the combination of both, and killed 3 h after surgery, showed cardiac sections with scattered lesions and only a few isolated injured muscle fibers. A similar effectiveness of melatonin and hGH, alone or in combination, to decrease injured area by 86 87% and the number of cardiac lesions by 75 80% was observed. CONCLUSION: A significant cytoprotective effect of melatonin or hGH is demonstrable in an early phase of myocardial infarction in rats. |
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Authors:
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Hugo E Castagnino; Néstor Lago; José M Centrella; Silvana D Calligaris; Silvia Fariña; María I Sarchi; Daniel P Cardinali |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuro endocrinology letters Volume: 23 ISSN: 0172-780X ISO Abbreviation: Neuro Endocrinol. Lett. Publication Date: 2002 Oct-Dec |
Date Detail:
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Created Date: 2002-12-24 Completed Date: 2003-03-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008373 Medline TA: Neuro Endocrinol Lett Country: Sweden |
Other Details:
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Languages: eng Pagination: 391-5 Citation Subset: IM |
Affiliation:
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Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coloring Agents Cytoprotection / drug effects* DNA / analysis Disease Models, Animal Drug Evaluation, Preclinical Drug Therapy, Combination Growth Hormone / therapeutic use* Heart / drug effects* Male Melatonin / therapeutic use* Myocardial Infarction / pathology, prevention & control* Myocardium / pathology Rats Rats, Wistar Rosaniline Dyes* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Feulgen stain; 0/Rosaniline Dyes; 73-31-4/Melatonin; 9002-72-6/Growth Hormone; 9007-49-2/DNA |
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