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Cytoprotection by Inhaled Carbon Monoxide before Cardiopulmonary Bypass in Preclinical Models.
MedLine Citation:
PMID:  22201608     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although a potentially toxic gaseous molecule, carbon monoxide recently gains rising scientifically and clinical interest as its beneficial effects and mechanisms of action are defined substantially in various in vitro and in vivo experiments. Its anti-inflammatory, anti-apoptotic and anti-proliferative properties but its increasing impact concerning numerous disease models in means of protection, well describe this gas as a new and challenging therapeutic alternative. In this review, we focus on the extensively analyzed advantageous value of pre- and postconditioning with inhaled carbon monoxide in the context of lung and kidney injury, induced by the low perfusion during and after cardiopulmonary bypass. Mechanisms like the heat shock response as well as an expanded view regarding toxicity and side effects are described broadly.
Authors:
Torsten Loop; Christian Schlensak; Ulrich Goebel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-1
Journal Detail:
Title:  Current pharmaceutical biotechnology     Volume:  -     ISSN:  1873-4316     ISO Abbreviation:  -     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2011-12-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960530     Medline TA:  Curr Pharm Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Anesthesiology and Critical Care Medicine and, Hugstetter Strasse 55, D-79106 Freiburg im Breisgau, Germany. torsten.loop@uniklinik-freiburg.de.
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