Document Detail


Cytoprotection by 16,16-dimethylprostaglandin E2. Role of gastric juice and mucus gel layer.
MedLine Citation:
PMID:  1629578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A mechanism of cytoprotection by 16,16-dimethylprostaglandin E2 (16,16-dimethyl-PGE2) was investigated in rats with respect to possible roles of the gastric juice and the mucus gel layer. 16,16-Dimethyl-PGE2 significantly increased the volume of gastric juice and mucus thickness. In a gastric juice-emptied stomach, 16,16-dimethyl-PGE2 protected the gastric mucosa against 30% ethanol, but not against 40% ethanol. Moreover, this agent did not show any cytoprotective action even against 30% ethanol when both gastric juice and mucus gel were removed. In this situation there was no histological change in the depth of injury, whether 16,16-dimethyl-PGE2 was given as pretreatment or not. These results suggest that there are two mechanisms that may play major roles in the cytoprotection of the gastric mucosa by 16,16-dimethyl-PGE2: (a) dilution of necrotizing agents by increased gastric juice and (b) thickening of the mucus gel layer.
Authors:
Y Taniguchi; Y Yoshida; K Kimura; M Mato
Related Documents :
23175518 - Breastfeeding and brain structure in adolescence.
23431448 - Stages of change model for participation in physical activity during pregnancy.
24413958 - Fantasies about the fetus in wanted and unwanted pregnancies.
3954708 - Air transport of the neonate with a congenital diaphragmatic hernia.
2898398 - Fetal biparietal diameter and head circumference measurements: results of a longitudina...
3244598 - Meconium peritonitis in stillbirths.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  14 Suppl 1     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1992  
Date Detail:
Created Date:  1992-08-14     Completed Date:  1992-08-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S52-8     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Jichi Medical School, Tochigi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Ethanol / administration & dosage,  adverse effects
Gastric Juice / drug effects*,  physiology
Gastric Mucosa / drug effects*,  pathology,  ultrastructure
Male
Microscopy, Electron, Scanning
Necrosis
Prostaglandins E, Synthetic / pharmacology*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Prostaglandins E, Synthetic; 41692-15-3/16,16-dimethylprostaglandin E; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of sofalcone on localization of 15-hydroxyprostaglandin dehydrogenase, an enzyme that metabol...
Next Document:  Early ultrastructural changes of surface epithelial cells isolated from rat gastric mucosa after exp...