| Cytoprotection by 16,16-dimethylprostaglandin E2. Role of gastric juice and mucus gel layer. | |
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MedLine Citation:
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PMID: 1629578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A mechanism of cytoprotection by 16,16-dimethylprostaglandin E2 (16,16-dimethyl-PGE2) was investigated in rats with respect to possible roles of the gastric juice and the mucus gel layer. 16,16-Dimethyl-PGE2 significantly increased the volume of gastric juice and mucus thickness. In a gastric juice-emptied stomach, 16,16-dimethyl-PGE2 protected the gastric mucosa against 30% ethanol, but not against 40% ethanol. Moreover, this agent did not show any cytoprotective action even against 30% ethanol when both gastric juice and mucus gel were removed. In this situation there was no histological change in the depth of injury, whether 16,16-dimethyl-PGE2 was given as pretreatment or not. These results suggest that there are two mechanisms that may play major roles in the cytoprotection of the gastric mucosa by 16,16-dimethyl-PGE2: (a) dilution of necrotizing agents by increased gastric juice and (b) thickening of the mucus gel layer. |
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Authors:
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Y Taniguchi; Y Yoshida; K Kimura; M Mato |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 14 Suppl 1 ISSN: 0192-0790 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-08-14 Completed Date: 1992-08-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S52-8 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Jichi Medical School, Tochigi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ethanol / administration & dosage, adverse effects Gastric Juice / drug effects*, physiology Gastric Mucosa / drug effects*, pathology, ultrastructure Male Microscopy, Electron, Scanning Necrosis Prostaglandins E, Synthetic / pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E, Synthetic; 41692-15-3/16,16-dimethylprostaglandin E; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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