Document Detail

Cytoprotection by 16,16-dimethylprostaglandin E2. Role of gastric juice and mucus gel layer.
MedLine Citation:
PMID:  1629578     Owner:  NLM     Status:  MEDLINE    
A mechanism of cytoprotection by 16,16-dimethylprostaglandin E2 (16,16-dimethyl-PGE2) was investigated in rats with respect to possible roles of the gastric juice and the mucus gel layer. 16,16-Dimethyl-PGE2 significantly increased the volume of gastric juice and mucus thickness. In a gastric juice-emptied stomach, 16,16-dimethyl-PGE2 protected the gastric mucosa against 30% ethanol, but not against 40% ethanol. Moreover, this agent did not show any cytoprotective action even against 30% ethanol when both gastric juice and mucus gel were removed. In this situation there was no histological change in the depth of injury, whether 16,16-dimethyl-PGE2 was given as pretreatment or not. These results suggest that there are two mechanisms that may play major roles in the cytoprotection of the gastric mucosa by 16,16-dimethyl-PGE2: (a) dilution of necrotizing agents by increased gastric juice and (b) thickening of the mucus gel layer.
Y Taniguchi; Y Yoshida; K Kimura; M Mato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  14 Suppl 1     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1992  
Date Detail:
Created Date:  1992-08-14     Completed Date:  1992-08-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S52-8     Citation Subset:  IM    
Department of Gastroenterology, Jichi Medical School, Tochigi, Japan.
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MeSH Terms
Ethanol / administration & dosage,  adverse effects
Gastric Juice / drug effects*,  physiology
Gastric Mucosa / drug effects*,  pathology,  ultrastructure
Microscopy, Electron, Scanning
Prostaglandins E, Synthetic / pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
0/Prostaglandins E, Synthetic; 41692-15-3/16,16-dimethylprostaglandin E; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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